Cell adhesion and communication in the corpus luteum-Function and regulation of tight and adherens junctions in the luteal vascular systemTranslation into pathophysiology Regulation of permeability in ovarian cancer

黄体中的细胞粘附和通讯-黄体血管系统中紧密连接和粘附连接的功能和调节转化为病理生理学卵巢癌通透性的调节

• 批准号: 146229695
• 负责人: Professorin Dr. Christine Wulff
• 金额: --
• 依托单位: Klinik für Frauenheilkunde und Geburtshilfe
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/146229695?language=en
• 关键词: Cell; adhesion; communication; corpus; luteum

From previous studies it is known that various cytokeratins and growth factors are involved in the regulation of adhesion proteins and in the regulation of permeability.We already demonstrated a physiological hCG mediated regulation of permeability between VEGF and the adhesion proteins VE-cadherin, claudin 5 and nectin 2 in an human corpus luteum model. Regardless of the hCG / VEGF / adhesion protein interaction we also examined a second system, the Robo / Slit system. There, we were able to find a direct VEGF-dependent downregulation of Slit 2/Robo in the CL. Based on these positive findings we firstly examined the permeability regulation of the human ovarian cancer ascites. Here we were able to detect a regulatory system between VEGF and claudin 5 with consequently increased permeability.With recourse to this pdata, we would now like to focus on the examination of more details about the adhesion proteins VE-cadherin, claudin 5 and nectin 2 in the corpus luteum as well as their interaction with the Robo / Slit System in physiological and pathophysiological models of the CL and the human ovarian cancer.

从以前的研究中，它是已知的，各种细胞角蛋白和生长因子参与调节的粘附蛋白和在调节的permeability.We已经证明了一个生理hCG介导的调节VEGF和粘附蛋白VE-钙粘蛋白，claudin 5和nectin 2在人黄体模型之间的渗透性。不管hCG / VEGF /粘附蛋白的相互作用，我们还研究了第二个系统，机器人/狭缝系统。在那里，我们能够发现CL中Slit 2/Robo的直接VEGF依赖性下调。基于这些阳性结果，我们首先研究了人卵巢癌腹水的渗透性调节。在这里，我们能够检测到VEGF和claudin 5之间的调节系统，从而增加了渗透性。借助于此pdata，我们现在想集中检查关于粘附蛋白VE-钙粘蛋白的更多细节，claudin 5和nectin 2在黄体中的表达及其与Robo /CL和人卵巢癌生理和病理生理模型中的Slit系统。

项目成果

Slit2/Robo4 Signaling: Potential Role of a VEGF-Antagonist Pathway to Regulate Luteal Permeability

• DOI: 10.1055/s-0042-113461
• 发表时间: 2017-01-01
• 期刊: GEBURTSHILFE UND FRAUENHEILKUNDE
• 影响因子: 2.7
• 作者: Bekes, I.;Haunerdinger, V.;Wulff, C.
• 通讯作者: Wulff, C.

Does VEGF facilitate local tumor growth and spread into the abdominal cavity by suppressing endothelial cell adhesion, thus increasing vascular peritoneal permeability followed by ascites production in ovarian cancer?

• DOI: 10.1186/s12943-016-0497-3
• 发表时间: 2016-02-12
• 期刊: Molecular cancer
• 影响因子: 37.3
• 作者: Bekes I;Friedl TW;Köhler T;Möbus V;Janni W;Wöckel A;Wulff C
• 通讯作者: Wulff C