Cell adhesion and communication in the corpus luteum-Function and regulation of tight and adherens junctions in the luteal vascular systemTranslation into pathophysiology Regulation of permeability in ovarian cancer

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From previous studies it is known that various cytokeratins and growth factors are involved in the regulation of adhesion proteins and in the regulation of permeability.We already demonstrated a physiological hCG mediated regulation of permeability between VEGF and the adhesion proteins VE-cadherin, claudin 5 and nectin 2 in an human corpus luteum model. Regardless of the hCG / VEGF / adhesion protein interaction we also examined a second system, the Robo / Slit system. There, we were able to find a direct VEGF-dependent downregulation of Slit 2/Robo in the CL. Based on these positive findings we firstly examined the permeability regulation of the human ovarian cancer ascites. Here we were able to detect a regulatory system between VEGF and claudin 5 with consequently increased permeability.With recourse to this pdata, we would now like to focus on the examination of more details about the adhesion proteins VE-cadherin, claudin 5 and nectin 2 in the corpus luteum as well as their interaction with the Robo / Slit System in physiological and pathophysiological models of the CL and the human ovarian cancer.