SBIR Phase I: Fabrication of High Aspect Ratio Microstructures in Polymers: Applications in Microcolumn Separations

SBIR 第一阶段：聚合物中高纵横比微结构的制造：在微柱分离中的应用

• 批准号: 0109430
• 负责人: Sean Ford
• 金额: $ 9.99万
• 依托单位: Mezzo Systems Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0109430&HistoricalAwards=false
• 关键词: SBIR; Phase; Fabrication; Aspect; Ratio

This Small Business Innovation Research (SBIR) Phase I project seeks to develop commercially viable methods for the fabrication of high aspect ratio micro- and nano-structures for microfluidic applications using contact nano-printing. X-ray lithography will be used to produce molding tools to emboss structures in polymers. Microfluidic channels will be fabricated with ordered arrays of micro- and nano-posts filling these channels. Molding tools will be constructed from metal electroform to allow hot embossing or injection molding of various polymers. Mechanical properties of both the electroform and the polymers will be evaluated for the ability to minimize structure deformation during demolding. Various gluing and heat annealing assembly methods to enclose the microfluidic channels will be investigated. A number of post geometries will be examined for feature integrity during molding, demolding and assembly. Fluid transport through the ordered arrays will be studied in detail using confocal fluorescence microscopy.The commercial applications of this project will be in the area of micro-column separations such as for reversed phase chromatography and for micro-reactors.

该小型企业创新研究（SBIR）第一阶段项目旨在开发商业上可行的方法，使用接触纳米印刷制造用于微流体应用的高纵横比微米和纳米结构。 X 射线光刻将用于生产用于在聚合物中压花结构的成型工具。微流体通道将由填充这些通道的微米和纳米柱的有序阵列制成。成型工具将由金属电铸件制成，以允许对各种聚合物进行热压花或注射成型。将评估电铸件和聚合物的机械性能，以评估脱模过程中最小化结构变形的能力。将研究封闭微流体通道的各种粘合和热退火组装方法。在成型、脱模和组装过程中，将检查许多后几何形状的特征完整性。将使用共焦荧光显微镜详细研究通过有序阵列的流体传输。该项目的商业应用将在微柱分离领域，例如反相色谱和微反应器。