SBIR Phase I: Novel Ultrasensitive Gas Chromatography (GC) Detector with Highly Specific Response to Aromatic Hydrocarbons

SBIR 第一阶段：对芳香烃具有高度特异性响应的新型超灵敏气相色谱 (GC) 检测器

• 批准号: 0109731
• 负责人: Brian Very
• 金额: $ 10万
• 依托单位: DAKOTA TECHNOLOGIES INC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0109731&HistoricalAwards=false
• 关键词: SBIR; Phase; Novel; Ultrasensitive; Gas

This Small Business Innovation Research (SBIR) Phase I project details the roadmap to rapid commercialization of a powerful new gas chromatography (GC) detector, the Aromatic Specific Laser Ionization Detector (ArSLID). Like a conventional photoionization detector (PID), the ArSLID creates ions by photoabsorption. But its two-photon laser ionization process confers many significant advantages over the PID, including: extraordinarily low limit of detection, potentially the lowest of any GC detector; extremely fast response ideally suited for fast GC; miniscule background signal; far higher selectivity for aromatic hydrocarbons; stable esponse over long periods of time; and compatible with all carrier gases, including air. Preliminary data taken with a prototype ArSLID already show the low background, selectivity, and sensitivity; it is as sensitive as any PID (ca. 1 pg toluene injected on-column). At least an order of magnitude further improvement will be achieved in Phase I with incorporation of a compact, low cost microchip laser ionization source that also offers much higher pulse repetition frequency and shot-to-shot stability compared to the laser source used to date.The ArSLID will find numerous applications that are difficult or impossible for a PID to meet. In the case of environmental analysis, the signals from the toxic and hazardous aromatic species (specifically the BTEX fraction) are too often buried in the aliphatic signals with a PID. Similarly, in pharmaceutical analysis, approximately 75% of the drugs contain an aromatic moiety and it is often challenging to find the drugs or their metabolites in the sea of endogenous compounds. It is estimated the annual sales of PIDs for GC detectors at $21 million and expect to rapidly capture a significant fraction of this market owing to the superior performance capabilities of the ArSLID.

这个小型企业创新研究（SBIR）第一阶段项目详细介绍了一种功能强大的新型气相色谱（GC）检测器--芳香族特异性激光电离检测器（ArSLID）的快速商业化路线图。 与传统的光电离检测器（PID）一样，ArSLID通过光吸收产生离子。 但它的双光子激光电离过程比PID具有许多显著的优点，包括：检测限极低，可能是任何GC检测器中最低的;非常适合快速GC的极快响应;极小的背景信号;对芳烃的选择性高得多;长时间稳定的响应;和所有载气兼容，包括空气。使用原型ArSLID获得的初步数据已经显示出低背景，选择性和灵敏度;它与任何PID一样灵敏（约100万美元）。1 μ g甲苯注入柱上）。 在第一阶段中，至少将实现一个数量级的进一步改进，其中包括一个紧凑、低成本的微芯片激光电离源，与迄今为止使用的激光源相比，该微芯片激光电离源还提供更高的脉冲重复频率和发射稳定性。ArSLID将发现许多PID难以或不可能满足的应用。在环境分析的情况下，来自有毒和危险的芳香族物质（特别是BTEX馏分）的信号经常被PID掩埋在脂肪族信号中。类似地，在药物分析中，大约75%的药物含有芳香族部分，并且在内源性化合物的海洋中发现药物或其代谢物通常具有挑战性。 据估计，气相色谱检测器PID的年销售额为2100万美元，由于ArSLID的上级性能，预计将迅速占领这一市场的很大一部分。