STTR Phase II: Cold Gas Dynamic Spray Processing of Bioactive Nano-hydroxyapatite/Titanium Nanocomposite Coatings

STTR第二阶段：生物活性纳米羟基磷灰石/钛纳米复合涂层的冷气动态喷涂加工

• 批准号: 0110323
• 负责人: Larry McCandlish
• 金额: $ 50万
• 依托单位: Ceramare Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2004-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0110323&HistoricalAwards=false
• 关键词: STTR; Phase; II; Cold; Gas

This Small Business Technology Transfer (STTR) Phase II Project will develop a fully integrated process for applying a well-bonded, bioactive coating to the stem of an orthopedic hip implant by a novel Cold Gas Dynamic Spray (CGDS), or Hyperkinetic Deposition process. The new process is a potential major advance in the state-of-the-art for surface modification of medical implants. The medical community hitherto has relied primarily on plasma spraying to activate implant surfaces. Plasma spraying is a cost-effective means of applying the coating material but is far from ideal. In particular, the high temperatures experienced by the hydroxyapatite feed powder during plasma spraying can seriously degrade its compositional integrity and thus its bioactive properties. The cold spray process eliminates this problem, and enables, for the first time, high-surface-area nanostructured hydroxyapatite powder to be incorporated into the implant surface withoutsacrificing its intrinsic bioactivity. As an added benefit the implant surface is left in a state of compression, which should extend the service life of the implant by eliminating the possibility of surface cracking caused by low-cycle fatigue.The commercial applications for this project will be to improve the life of implants.

这个小型企业技术转移(STTR)第二阶段项目将开发一种完全集成的工艺，通过一种新型的冷气动态喷涂(CGDS)或超动力沉积工艺，在骨科髋关节植入物的支架上应用结合良好的生物活性涂层。这一新工艺是医疗植入物表面改性最先进的潜在重大进步。到目前为止，医学界主要依靠等离子喷涂来激活植入物表面。等离子喷涂是应用涂层材料的一种经济有效的方法，但远不理想。特别是，羟基磷灰石原料粉末在等离子喷涂过程中经历的高温会严重降低其成分完整性，从而降低其生物活性。冷喷涂工艺消除了这一问题，并首次使高比表面积纳米结构羟基磷灰石粉末能够在不牺牲其固有生物活性的情况下被结合到植入物表面。作为一个额外的好处，种植体表面处于压缩状态，这将通过消除低周疲劳引起的表面裂纹的可能性来延长种植体的使用寿命。该项目的商业应用将是提高种植体的寿命。