The Kinetic Resolution of Chiral alpha-Olefins with Optically Active Ansa-Zirconocene Polymerization Catalysts

光学活性柄型二茂锆聚合催化剂动力学拆分手性 α-烯烃

• 批准号: 0131180
• 负责人: John Bercaw
• 金额: $ 49.5万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0131180&HistoricalAwards=false
• 关键词: Kinetic; Resolution; Chiral; alpha; Olefins

The objective of this research by Professor John E. Bercaw at the California Institute of Technology, which is supported by the Inorganic, Bioinorganic and Oganometallic Chemistry Program, is to develop new, highly reactive enantiopure precatalysts that show improved selectivity and substrate generality for chiral alpha-olefins. Due to their extreme activities in polymerizing alpha-olefins, optically active ansa-zirconocene polymerization catalysts are excellent prospects for effecting kinetic resolutions, preferentially polymerizing one enantiomer of a chiral olefin and leaving behind the less reactive enantiomer. This not only resolves the two enantiomers, but also leads to a new class of optically active polymers.New catalysts will be developed to resolve right- and left handed molecules, which is essential for synthesizing chiral molecules such as pharmaceuticals. By using a polymerization catalyst, one type of "handed" molecule is incorporated into a new type of "handed" polymer.

加州理工学院 John E. Bercaw 教授的这项研究得到了无机、生物无机和有机金属化学项目的支持，其目的是开发新型高反应性对映体纯预催化剂，提高手性 α-烯烃的选择性和底物通用性。 由于其在聚合α-烯烃中的极端活性，光学活性柄型二茂锆聚合催化剂在实现动力学拆分、优先聚合手性烯烃的一种对映体并留下反应性较低的对映体方面具有极好的前景。 这不仅可以解析两种对映体，还可以产生一类新型光学活性聚合物。将开发新的催化剂来解析右旋和左旋分子，这对于合成药物等手性分子至关重要。 通过使用聚合催化剂，一种类型的“手性”分子被结合到一种新型的“手性”聚合物中。