Mississippi EPSCoR Research Infrastructure Improvement Program

密西西比 EPSCoR 研究基础设施改善计划

• 批准号: 0132618
• 负责人: Colin Scanes
• 金额: $ 600万
• 依托单位: Mississippi State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-15 至 2006-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0132618&HistoricalAwards=false
• 关键词: Mississippi; EPSCoR; Research; Infrastructure; Improvement

The Mississippi Research Infrastructure Improvement Program builds on successful previous investments and targets five areas:1)Nanostructured Silicate Systems with Designed Molecular and Supermolecular Architecture in Hybrid Organic/Inorganic Materials; 2) Computational Chemistry; 3) Integrating Molecular, Cellular and Organismal Responses of Bioregulatory Systems to Environmental Stressors; 4) Protein Structure and Localization; and 5) Computational Simulation and Information Technology. The Nanostructured Silicate Systems group involves chemists, physicists and polymer scientists/engineers. It will develop nanostructured silicate systems and "molecular silicas" to exploit the potential for the design of novel materials with macroscopic properties that are a direct consequence of the unique nanoscopic properties of the finely dispersed heterogeneous components. The Computational Chemistry research group will concentrate on fundamental problems of potential energy surfaces, geometry and structure of inclusion complexes, hydrogen bonding in ground and excited states, and ring strain while improving computational efficiencies of the methods employed. The research group involved with Integrating Molecular, Cellular and Organismal Responses to Stress will investigate the biochemical, physiological and behavioral responses of the bioregulatory systems of animals and plants brought about by chemical and other stressors, including delineation of changes in the proteome during stress responses. The Protein Structure and Localization group will investigate structures known to have important physiological roles and involves identifying the compartment(s), in which protein acts, including movement from one compartment to another that often regulates protein function. They will use relatively low-resolution tools in conjunction with computational methods to recognize domains and other elements of tertiary structure. The Computational Simulation and Information Technology group will provide high performance computing and information technology support to the other research areas. The research infrastructure improvement project includes researchers at the University of Mississippi (UM), the University of Mississippi Medical Center (UMMC), the University of Southern Mississippi (USM), Jackson State University (JSU), Mississippi State University MSU), and Mississippi College (MC). Cross-cutting computational support will be provided by the Mississippi State University Engineering Research Center.In addition to the research effort, the Mississippi infrastructure improvement plan includes support for activities to strengthen the campus environment for research. This support includes faculty start-up funds, equipment, travel and stipends for undergraduate and graduate students. Staff development activities such as seminars and workshops, commercialization assistance, subscription services etc. will also be available to further strengthen the research environment. The Mississippi project also includes focused activities designed to increase the participation of women and members of other underrepresented groups in the activities of the award.

密西西比州研究基础设施改进计划建立在以前成功投资的基础上，目标是五个领域：1)具有在有机/无机杂化材料中设计的分子和超分子结构的纳米硅酸盐系统；2)计算化学；3)整合生物调节系统对环境压力的分子、细胞和组织响应；4)蛋白质结构和定位；以及5)计算模拟和信息技术。纳米结构硅酸盐系统小组由化学家、物理学家和聚合物科学家/工程师组成。它将开发纳米结构硅酸盐系统和“分子二氧化硅”，以开发设计具有宏观性能的新材料的潜力，这些宏观性能直接归因于精细分散的非均质组分的独特纳米特性。计算化学研究小组将专注于势能面、包合物的几何和结构、基态和激发态的氢键以及环应变等基本问题，同时提高所用方法的计算效率。参与整合分子、细胞和组织对应激反应的研究小组将研究化学和其他应激因素带来的动植物生物调节系统的生化、生理和行为反应，包括描绘应激反应过程中蛋白质组的变化。蛋白质结构和定位小组将研究已知具有重要生理作用的结构，并涉及识别蛋白质在其中发挥作用的隔室(S)，包括从一个隔室到通常调节蛋白质功能的另一个隔室的运动。他们将使用相对低分辨率的工具结合计算方法来识别结构域和其他三级结构元素。计算模拟和信息技术小组将为其他研究领域提供高性能计算和信息技术支持。研究基础设施改善项目包括密西西比大学(UM)、密西西比大学医学中心(UMMC)、南密西西比大学(USM)、杰克逊州立大学(JSU)、密西西比州立大学(密西西比州立大学)和密西西比学院(MC)的研究人员。密西西比州立大学工程研究中心将提供交叉计算支持。除了研究工作，密西西比州基础设施改善计划还包括支持加强校园研究环境的活动。这些支持包括教师启动资金、设备、旅费以及本科生和研究生的津贴。还将开展工作人员发展活动，如研讨会和讲习班、商业化援助、订阅服务等，以进一步加强研究环境。密西西比州项目还包括有重点的活动，旨在增加妇女和其他代表性不足群体成员对该奖项活动的参与。