Minority Postdoctoral Research Fellowship for FY 2002

这项行动为2002财政年度NSF少数民族博士后研究奖学金提供资金。该研究金的目标是培养少数民族科学家担任学术界和工业界的科学领导职务。为了实现这一目标，奖学金提供最高质量的博士后培训机会，以最近的博士获奖者。该计划是美国国家科学基金会的一项努力，旨在增加来自代表性不足的少数群体的研究科学家的数量，从而为国家科学事业的未来活力做出贡献。预计通过这些奖学金培训的研究员将在培训未来的劳动力方面发挥重要作用。该奖学金的研究和培训计划名为“可能启动细胞转化的Cdc42Hs突变蛋白的结构研究”。核磁共振光谱学被用来表征Cdc42H的突变形式，Cdc42H是一种在E.杆菌该蛋白结合GTP或GDP，并根据结合配体的性质作为分子定时开关。该研究将确定两个Cdc42Hs突变体的结构和动力学，以了解Cdc42Hs在导致细胞转化的过程中的作用。

This action funds an NSF Minority Postdoctoral Research Fellowship for FY2002. The goal of the fellowship is to prepare minority scientists for positions of scientific leadership in academia and industry. To attain this goal, the fellowship provides opportunities for postdoctoral training of the highest quality to recent doctoral recipients. This program is an effort by the NSF to increase the number of research scientists from underrepresented minority groups, thereby contributing to the future vitality of the Nation's scientific enterprise. It is expected that Fellows trained through these fellowships will play important roles in training of the future workforce.The research and training plan for this fellowship is entitled "Structural studies on Cdc42Hs mutant proteins that may initiate cellular transformation." NMR spectroscopy is being used to characterize mutant forms of Cdc42Hs, an intracellular signal transduction protein cloned in E. coli. This protein binds GTP or GDP and acts as a molecular timing switch based on the nature of the bound ligand. The research will determine the structure and dynamics of two Cdc42Hs mutants to understand the role of Cdc42Hs in processes that lead to cell transformation.