Phenotype and function of CD4+ T lymphocytes in autoimmune hepatitis (B05)

自身免疫性肝炎中CD4 T淋巴细胞的表型和功能（B05）

• 批准号: 158253468
• 金额: --
• 依托单位: I. Medizinische Klinik und Poliklinik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/158253468?language=en
• 关键词: Phenotype; function; CD4+; lymphocytes; autoimmune

CD4+ T lymphocytes play a key role in pathogenesis of autoimmune hepatitis. We seek to characterize the phenotype and function of CD4+ T lymphocytes and to identify the autoantigen targeted by the T cells. As TNF secretion seems to characterize these pathogenic T-cells, we plan a clinical study using infliximab as a steroid-substitute in inducing remission in patients with newly diagnosed autoimmune hepatitis.

CD4+ T淋巴细胞在自身免疫性肝炎的发病机制中起关键作用。我们试图描述CD4+ T淋巴细胞的表型和功能，并确定T细胞靶向的自身抗原。由于TNF分泌似乎是这些致病性T细胞的特征，我们计划使用英夫利西单抗作为类固醇替代品诱导新诊断的自身免疫性肝炎患者缓解的临床研究。