RUI: Regioselective Syntheses of Heterocycles and their Applications

RUI：杂环化合物的区域选择性合成及其应用

• 批准号: 0212699
• 负责人: Charles Beam
• 金额: $ 18.2万
• 依托单位: College of Charleston
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0212699&HistoricalAwards=false
• 关键词: RUI; Regioselective; Syntheses; Heterocycles; their

The research in this project will focus on the preparation and study of azoles, primarily pyrazoles and isoxazoles, and pyranones. For the syntheses, some emphasis is placed on multiple anion-type syntheses coupled with standard preparative methodology as exemplified by Claisen-type reactions, aldol-type reactions and alkylations. Starting materials will consist of readily available ketones, hydrazones and carboxylic acid hydrazides. Each of the projects will be organized into smaller component investigations thereby allowing each undergraduate participant to be involved in at least two investigations.With this Research in Undergraduate Institutions (RUI) award, the Organic and Macromolecular Chemistry Program is supporting the research efforts of Dr. Charles F. Beam and Dr. Jason S. Overby of the Department of Chemistry and Biochemistry at the College/University of Charleston. The principal investigators will focus their work on the preparation of heterocycles that have interesting biological activity, that have interesting ligand properties and compounds that are viable ligands for the construction of new metallocene derivatives. The students working in the project will have the opportunity to gain from the experience of both an organic and an inorganic chemist.

该项目的研究将集中于唑类（主要是吡唑和异恶唑）以及吡喃酮的制备和研究。 对于合成，重点放在多种阴离子型合成以及标准制备方法上，例如克莱森型反应、羟醛型反应和烷基化。 起始材料将由容易获得的酮、腙和羧酸酰肼组成。 每个项目将被组织成较小的组成部分的调查，从而允许每个本科生参与者至少参与两项调查。通过本科机构研究（RUI）奖，有机和高分子化学项目正在支持查尔斯顿学院/大学化学和生物化学系的 Charles F. Beam 博士和 Jason S. Overby 博士的研究工作。 主要研究人员的工作重点是制备具有有趣的生物活性、具有有趣的配体特性的杂环化合物以及作为构建新茂金属衍生物的可行配体的化合物。 参与该项目的学生将有机会从有机和无机化学家的经验中获益。