RUI: Regioselective Syntheses of Heterocycles and their Applications

本项目的研究重点是唑类化合物（主要是吡唑和异恶唑）和吡喃酮的制备和研究。 对于合成，一些重点放在多阴离子型合成加上标准的制备方法，如克莱森型反应，醛醇型反应和烷基化。 起始物料将由容易获得的酮、腙和羧酸酰肼组成。 每个项目将被组织成更小的组成部分的调查，从而使每个本科生参与者参与至少两个调查。有了这个研究在本科院校（RUI）奖，有机和高分子化学计划是支持博士的研究工作。Beam和Jason S.奥弗比的化学和生物化学系在学院/大学的查尔斯顿。 主要研究人员将把工作重点放在制备具有有趣的生物活性的杂环，具有有趣的配体特性和化合物，这些化合物是构建新茂金属衍生物的可行配体。 在该项目中工作的学生将有机会从有机和无机化学家的经验中获益。

The research in this project will focus on the preparation and study of azoles, primarily pyrazoles and isoxazoles, and pyranones. For the syntheses, some emphasis is placed on multiple anion-type syntheses coupled with standard preparative methodology as exemplified by Claisen-type reactions, aldol-type reactions and alkylations. Starting materials will consist of readily available ketones, hydrazones and carboxylic acid hydrazides. Each of the projects will be organized into smaller component investigations thereby allowing each undergraduate participant to be involved in at least two investigations.With this Research in Undergraduate Institutions (RUI) award, the Organic and Macromolecular Chemistry Program is supporting the research efforts of Dr. Charles F. Beam and Dr. Jason S. Overby of the Department of Chemistry and Biochemistry at the College/University of Charleston. The principal investigators will focus their work on the preparation of heterocycles that have interesting biological activity, that have interesting ligand properties and compounds that are viable ligands for the construction of new metallocene derivatives. The students working in the project will have the opportunity to gain from the experience of both an organic and an inorganic chemist.