RUI: Regioselective Syntheses of Heterocycles and their Applications

本项目将重点研究唑类化合物的制备和研究，主要是吡唑类和异恶唑类化合物以及吡喃酮类化合物。对于合成，一些重点放在多阴离子型合成加上标准的制备方法，如克莱森型反应，醛型反应和烷基化反应。起始原料将由现成的酮类、腙类和羧酸肼类组成。每个项目将被组织成较小的组成部分调查，从而允许每个本科生参与者参与至少两个调查。有机和大分子化学项目通过本科院校研究（RUI）奖，支持查尔斯顿学院/大学化学与生物化学系的查尔斯·f·比姆博士和杰森·s·奥弗比博士的研究工作。主要研究人员将把他们的工作集中在制备具有有趣的生物活性的杂环，具有有趣的配体性质的杂环，以及作为构建新的茂金属衍生物的可行配体的化合物。参与该项目的学生将有机会获得有机和无机化学家的经验。

The research in this project will focus on the preparation and study of azoles, primarily pyrazoles and isoxazoles, and pyranones. For the syntheses, some emphasis is placed on multiple anion-type syntheses coupled with standard preparative methodology as exemplified by Claisen-type reactions, aldol-type reactions and alkylations. Starting materials will consist of readily available ketones, hydrazones and carboxylic acid hydrazides. Each of the projects will be organized into smaller component investigations thereby allowing each undergraduate participant to be involved in at least two investigations.With this Research in Undergraduate Institutions (RUI) award, the Organic and Macromolecular Chemistry Program is supporting the research efforts of Dr. Charles F. Beam and Dr. Jason S. Overby of the Department of Chemistry and Biochemistry at the College/University of Charleston. The principal investigators will focus their work on the preparation of heterocycles that have interesting biological activity, that have interesting ligand properties and compounds that are viable ligands for the construction of new metallocene derivatives. The students working in the project will have the opportunity to gain from the experience of both an organic and an inorganic chemist.