SBIR Phase I: A New Solid State Surgical Imaging Probe
SBIR Phase I: A New Solid State Surgical Imaging Probe
批准号:
0214881
负责人:
Gerald Entine
金额:
$10.0万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-07-01 至 2002-12-31
中文摘要
这个小企业创新研究(SBIR)第一阶段项目提出开发一种新的术中成像探头,该探头基于一个固态、紧凑型读出传感器,耦合到一个高分辨率、高光输出转换器。核医学成像已广泛应用于术前对切除活检感兴趣的结构进行成像。利用非成像伽马探测器和放射性示踪剂的无线电引导术中程序促进了一种成本效益高、高度特异性的方法来定位可疑组织并进行病理分析。放射引导手术的结果是增加了活检的组织特异性,获得了最小的切口,减少了住院病人的住院利用率,改善了病人的康复。非成像伽马引导的主要缺点是缺乏被测区域的辅助信息,例如两个相邻放射性区域的区分,这可以通过术中成像探头来克服。此外,来自身体其他部位的高穿透性伽马辐射增加了本底,限制了电流探头的实际使用。这个i期项目旨在通过设计新一代术中探针来解决这些局限性,该探针旨在用短距离β射线对肿瘤床进行成像。当发展,这种检测器将允许准确描绘肿瘤,从而促进精确切除。该项目的商业应用是在生物医学设备和仪器领域。
英文摘要
This Small Business Innovation Research (SBIR) Phase I project proposes to develop a new intraoperative imaging probe based on a solid-state, compact readout sensor coupled to a high resolution, high light output converter. Nuclear Medicine imaging has been widely used to preoperatively image structures of interest for excisional biopsy. Radio-guided intraoperative procedures utilizing non-imaging gamma detector probes and radiotracers have facilitated a cost-effective, highly specific means to locate suspect tissue and access it for pathologic analysis. The result of radio-guided surgery is increased tissue specificity obtained for biopsy, minimally accessed incisions, and the reduction of inpatient hospital utilization with an improved patient recovery. The main drawback of non- imaging gamma guidance is the lack of ancillary information of the surveyed area, such as distinction between two neighboring radioactive regions, which can be overcome with an intraoperative imaging probe. Also, the highly penetrating gamma radiation from other parts of the body increases the background, and limits the practical use of current probes. This Phase i project seeks to address these limitations by designing a new-generation intraoperative probe intended to image the tumor bed with short-range beta rays. When developed, this detector will allow accurate delineation of the tumor, thus facilitating precise resection.The commercial application of this project is in the area of biomedical devices and instrumentation.
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