SBIR Phase I: A New Solid State Surgical Imaging Probe

SBIR 第一阶段：新型固态手术成像探头

• 批准号: 0214881
• 负责人: Gerald Entine
• 金额: $ 10万
• 依托单位: Radiation Monitoring Devices Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0214881&HistoricalAwards=false
• 关键词: SBIR; Phase; New; Solid; State

This Small Business Innovation Research (SBIR) Phase I project proposes to develop a new intraoperative imaging probe based on a solid-state, compact readout sensor coupled to a high resolution, high light output converter. Nuclear Medicine imaging has been widely used to preoperatively image structures of interest for excisional biopsy. Radio-guided intraoperative procedures utilizing non-imaging gamma detector probes and radiotracers have facilitated a cost-effective, highly specific means to locate suspect tissue and access it for pathologic analysis. The result of radio-guided surgery is increased tissue specificity obtained for biopsy, minimally accessed incisions, and the reduction of inpatient hospital utilization with an improved patient recovery. The main drawback of non- imaging gamma guidance is the lack of ancillary information of the surveyed area, such as distinction between two neighboring radioactive regions, which can be overcome with an intraoperative imaging probe. Also, the highly penetrating gamma radiation from other parts of the body increases the background, and limits the practical use of current probes. This Phase i project seeks to address these limitations by designing a new-generation intraoperative probe intended to image the tumor bed with short-range beta rays. When developed, this detector will allow accurate delineation of the tumor, thus facilitating precise resection.The commercial application of this project is in the area of biomedical devices and instrumentation.

该小型企业创新研究（SBIR）第一阶段项目提出开发一种新的术中成像探头，该探头基于固态紧凑型读出传感器，并与高分辨率、高光输出转换器耦合。核医学成像已广泛用于对切除活检的感兴趣结构进行术前成像。利用非成像伽马探测器探头和放射性示踪剂的放射引导术中手术促进了定位可疑组织并进入其进行病理分析的具有成本效益的高度特异性的手段。放射引导手术的结果是增加了活检的组织特异性，最小限度地进入切口，减少了住院病人的医院利用率，改善了患者的恢复。非成像伽马引导的主要缺点是缺乏所调查区域的辅助信息，例如两个相邻放射性区域之间的区别，这可以用术中成像探头来克服。此外，来自身体其他部位的高穿透性伽马辐射增加了本底，并限制了当前探头的实际使用。该I期项目旨在通过设计新一代术中探头来解决这些局限性，该探头旨在使用短程β射线对肿瘤床进行成像。当开发完成后，这种探测器将允许精确描绘肿瘤，从而促进精确切除。该项目的商业应用是在生物医学设备和仪器领域。