The effect of AMP-activated protein kinase on endothelial energy metabolism and the consequences for angiogenesis and signalling (A05)

AMP 激活蛋白激酶对内皮能量代谢的影响以及对血管生成和信号传导的影响 (A05)

• 批准号: 159036169
• 金额: --
• 依托单位: Vascular Research Center
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/159036169?language=en
• 关键词: effect; AMP; activated; protein; kinase

The AMP-activated protein kinase (AMPK) is an energy-sensing kinase that occupies a unique position as a regulator of metabolism and signalling. The AMPK augments endothelial glycolysis and mitochondrial function at the same time as inhibiting cholesterol and isoprene synthesis. The aims of this project are to identify novel endothelial targets of the AMPK that are involved in angiogenesis and endothelial cell energy metabolism as well as to identify novel interactions between metabolism and other signalling pathways that contribute to endothelial signalling and vascular repair.

AMP激活的蛋白激酶（AMPK）是一种能量敏感激酶，作为代谢和信号传导的调节剂占据独特的地位。AMPK在抑制胆固醇和异戊二烯合成的同时增强内皮糖酵解和线粒体功能。该项目的目的是确定参与血管生成和内皮细胞能量代谢的AMPK的新型内皮靶点，以及确定代谢与其他有助于内皮信号传导和血管修复的信号传导途径之间的新型相互作用。