The effect of AMP-activated protein kinase on endothelial energy metabolism and the consequences for angiogenesis and signalling (A05)

AMP激活的蛋白激酶(AMPK)是一种能量敏感的蛋白激酶，在新陈代谢和信号转导中占有独特的地位。AMPK在增强内皮糖酵解和线粒体功能的同时，抑制胆固醇和异戊二烯的合成。这个项目的目的是确定AMPK的新的内皮靶点，参与血管生成和内皮细胞的能量代谢，以及确定代谢和其他有助于内皮信号和血管修复的信号通路之间的新的相互作用。

The AMP-activated protein kinase (AMPK) is an energy-sensing kinase that occupies a unique position as a regulator of metabolism and signalling. The AMPK augments endothelial glycolysis and mitochondrial function at the same time as inhibiting cholesterol and isoprene synthesis. The aims of this project are to identify novel endothelial targets of the AMPK that are involved in angiogenesis and endothelial cell energy metabolism as well as to identify novel interactions between metabolism and other signalling pathways that contribute to endothelial signalling and vascular repair.