Polyphile Moleküle mit membranmodifizierenden Eigenschaften

具有膜改性特性的多亲性分子

• 批准号: 161161649
• 负责人: Professor Dr. Carsten Tschierske
• 金额: --
• 依托单位: Department of Materials Science and Engineering
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/161161649?language=en
• 关键词: Polyphile; Molek; le; mit; membranmodifizierenden

The project aims to the synthesis and systematic investigation of the self-assembly of T-shaped and X-shaped low molecular weight polyphilic molecules in aqueous systems and the investigation of the interaction with phospholipide model membranes. For this purpose new T- and X-shaped polyphiles with extended hydrophilic units will be synthesized. The aggregation of these polyphiles in aqueous systems will be investigated over a broad concentration range from micellar solutions via lyotropic LC phases to swollen and solvent-free thermotropic LC systems. The development of the superstructures depending on the molecular structure will be studied systematically. The effects of these polyphiles on phospholipide model membranes, such as compartmentalization and formation of pores, are of special interest. Relations between molecular structure, superstructures in aqueous systems and membrane modifying effects will be systematically investigated.

该项目旨在合成和系统研究T型和X型低分子量多亲性分子在水体系中的自组装以及与磷脂模型膜的相互作用的研究。为此目的，将合成具有扩展亲水单元的新T型和X型亲水剂。这些亲多亲物在水性系统中的聚集将在广泛的浓度范围内进行研究，从胶束溶液通过溶致液晶相到溶胀且无溶剂的热致液晶系统。将系统地研究取决于分子结构的上层建筑的发展。这些亲多性物质对磷脂模型膜的影响，例如区室化和孔的形成，特别令人感兴趣。将系统地研究水体系中的分子结构、超结构和膜改性效果之间的关系。