Polyphile Moleküle mit membranmodifizierenden Eigenschaften

该项目旨在合成和系统研究T型和X型低分子多亲分子在水体系中的自组装以及与磷脂模型膜的相互作用。为此目的，将合成具有扩展亲水单元的新的T型和X型多亲分子。这些多聚体在水体系中的聚集将被研究在从胶束溶液到溶致LC相到溶胀和无溶剂的热致LC体系的广泛浓度范围内。我们将系统地研究超结构的发展与分子结构的关系。这些多聚体对磷脂模型膜的影响，如区隔和孔的形成，是特别感兴趣的。将系统地研究分子结构、水体系中的超结构与膜修饰效果之间的关系。

The project aims to the synthesis and systematic investigation of the self-assembly of T-shaped and X-shaped low molecular weight polyphilic molecules in aqueous systems and the investigation of the interaction with phospholipide model membranes. For this purpose new T- and X-shaped polyphiles with extended hydrophilic units will be synthesized. The aggregation of these polyphiles in aqueous systems will be investigated over a broad concentration range from micellar solutions via lyotropic LC phases to swollen and solvent-free thermotropic LC systems. The development of the superstructures depending on the molecular structure will be studied systematically. The effects of these polyphiles on phospholipide model membranes, such as compartmentalization and formation of pores, are of special interest. Relations between molecular structure, superstructures in aqueous systems and membrane modifying effects will be systematically investigated.