CASTOR and POLLUX, two ion channels required for perinuclear calcium-spiking

CATOR 和 POLLUX，核周钙尖峰所需的两个离子通道

• 批准号: 162634482
• 负责人: Professor Dr. Martin Parniske
• 金额: --
• 依托单位: Institut für Genetik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/162634482?language=en
• 关键词: CASTOR; POLLUX; two; ion; channels

CASTOR and POLLUX are essential for plant root endosymbiois with bacteria and fungi. In particular, they are required for symbiosis-induced, perinuclear calcium oscillations called calcium spiking. The mechanism underlying perinuclear calcium spiking induced during legume root endosymbiosis is largely unknown. We have shown that CASTOR and POLLUX from Lotus japonicus represent a new class of ion channels, suggesting an involvement in the mechanism of calcium spiking. To further unravel their function, we propose to study the regulation of the channel proteins and to further characterize their electrophysiological properties. We will also study proteins that interact with CASTOR or POLLUX in order to identify additional complex components and potentially regulators.

Castor和POLLUX是植物根与细菌和真菌内共生所必需的。特别是，它们需要共生诱导的，核周钙振荡称为钙尖峰。豆科植物根内共生过程中引起的核周钙尖峰的机制还很不清楚。我们已经表明，蓖麻和POLLUX从莲花代表一类新的离子通道，这表明参与机制的钙尖峰。为了进一步阐明它们的功能，我们建议研究通道蛋白的调节，并进一步表征它们的电生理特性。我们还将研究与Castor或POLLUX相互作用的蛋白质，以确定其他复杂的组分和潜在的调节剂。

项目成果

The Recent Evolution of a Symbiotic Ion Channel in the Legume Family Altered Ion Conductance and Improved Functionality in Calcium Signaling[C][W]

• DOI: 10.1105/tpc.112.098475
• 发表时间: 2012-06
• 期刊: Plant Cell
• 影响因子: 11.6
• 作者: Muthusubramanian Venkateshwaran;Ana M Cosme;Lu Han;M. Banba;K. Satyshur;E. Schleiff;M. Parniske;H. Imaizumi-Anraku;Jean-Michel Ané