PostDoctoral Research Fellowship

博士后研究奖学金

• 批准号: 0309904
• 负责人: Graciela Cabana
• 金额: $ 10万
• 依托单位: Cabana, Graciela S
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0309904&HistoricalAwards=false
• 关键词: PostDoctoral; Research; Fellowship

This NSF Minority Post Doctoral Research Fellowship will support research and training for a minority scholar to work in molecular anthropology, specifically for a Y chromosome-based study on the genetic diversity of Native Peruvian populations. The project will provide the researcher extensive training experience in method and theory of molecular anthropology, and this training will both complement and supplement her previous Ph.D. work at the University of Michigan. This two-year project will be carried out primarily in the laboratory of Dr. Anne C. Stone of the University of New Mexico, supplemented with occasional collaborative training and technical work with Dr.B.Lizarraga, Universidad Nacional Mayor de San Marcos, and V.Rubin, Universidad Ricardo Palma, Lima, Peru. The proposed project is in depth study of Native Peruvian Y chromosome genetic diversity. Specifically, the project aims to: (1) characterize Y chromosomal genetic diversity in Native Peruvian groups via intensive population sampling, (2) test for significant correlations between genetic diversity measures, on the one hand, and variables that may have shaped genetic structure of these native populations, including past demographic events, on the other, and (3) conduct these tests on both a regional (Peruvian / Andean) and continental (SouthAmerican) scale. The study focuses on the non-recombining component (NRY) of the chromosome to resolve the population genetic structure of Native Peruvian populations. Population affinity, level of genetic diversity and gene flow will be examined using population genetic analyses. Y chromosomal haplotypes will form the basis of these comparisons, and these will be constructed using combinations of relatively slow mutating Single Nucleotide Polymorphisms (SNPs) and faster mutating Short Tandem Repeats (STRs). Thus far, Dr. Lizarraga and V. Rubin have sampled over 100 individuals from 6 populations throughout diverse geographic areas and linguistic families for the purposes of this project.

NSF少数民族博士后研究奖学金将支持研究和培训少数民族学者从事分子人类学工作，特别是对秘鲁土著人口遗传多样性的Y染色体研究。该项目将为研究人员提供分子人类学方法和理论方面的广泛培训经验，这种培训将补充和补充她以前的博士学位。在密歇根大学工作这个为期两年的项目将主要在Anne C.新墨西哥州大学的斯通，辅之以偶尔与圣马科斯国立大学的B.Lizarraga博士和秘鲁利马的里卡多帕尔马大学的V.Rubin的合作培训和技术工作。拟议的项目是深入研究秘鲁土著Y染色体遗传多样性。具体而言，该项目旨在：（1）通过密集的人口抽样，确定秘鲁土著群体中Y染色体遗传多样性的特征，（2）检验遗传多样性措施与可能塑造这些土著群体遗传结构的变量（包括过去的人口统计事件）之间的显著相关性，以及（3）在区域（秘鲁/安第斯）和大陆（南美）规模上进行这些试验。这项研究的重点是染色体的非重组成分（NRY），以解决秘鲁土著人口的群体遗传结构。将使用群体遗传分析来检查群体亲和力、遗传多样性水平和基因流动。Y染色体单倍型将形成这些比较的基础，并且这些单倍型将使用相对缓慢突变的单核苷酸多态性（SNP）和更快突变的短串联重复序列（STR）的组合来构建。到目前为止，Lizarraga博士和V. Rubin博士已经从不同地理区域和语言家族的6个种群中抽取了100多个个体，用于本项目。