PostDoctoral Research Fellowship

NSF少数民族博士后研究奖学金将支持少数民族学者从事分子人类学工作的研究和培训，特别是基于Y染色体的秘鲁土著人口遗传多样性研究。该项目将为研究人员提供广泛的分子人类学方法和理论方面的培训经验，这次培训将补充和补充她之前在密歇根大学的博士工作。这个为期两年的项目将主要在新墨西哥大学的Anne C.Stone博士的实验室进行，并与圣马科斯大学国家市长B.Lizarraga博士和秘鲁利马Ricardo Palma大学的V.Rubin博士偶尔进行合作培训和技术工作。建议的项目是深入研究秘鲁原住民Y染色体遗传多样性。具体地说，该项目旨在：(1)通过密集的人口抽样，确定秘鲁土著群体Y染色体遗传多样性的特征；(2)一方面测试遗传多样性措施与可能影响这些土著人口遗传结构的变量之间的显著相关性，包括过去的人口统计事件；以及(3)在区域(秘鲁/安第斯山脉)和大陆(南美洲)规模上进行这些测试。本研究以染色体的非重组成分(NRY)为研究对象，对秘鲁原住民群体遗传结构进行解析。将使用种群遗传分析来检查种群亲和力、遗传多样性水平和基因流动。Y染色体单倍型将构成这些比较的基础，这些单倍型将使用相对缓慢的突变单核苷酸多态(SNPs)和较快的突变短串联重复序列(STR)的组合来构建。到目前为止，Lizarraga博士和V.Rubin博士为了这个项目的目的，已经从不同地理区域和语言家族的6个种群中抽取了100多个个体。

This NSF Minority Post Doctoral Research Fellowship will support research and training for a minority scholar to work in molecular anthropology, specifically for a Y chromosome-based study on the genetic diversity of Native Peruvian populations. The project will provide the researcher extensive training experience in method and theory of molecular anthropology, and this training will both complement and supplement her previous Ph.D. work at the University of Michigan. This two-year project will be carried out primarily in the laboratory of Dr. Anne C. Stone of the University of New Mexico, supplemented with occasional collaborative training and technical work with Dr.B.Lizarraga, Universidad Nacional Mayor de San Marcos, and V.Rubin, Universidad Ricardo Palma, Lima, Peru. The proposed project is in depth study of Native Peruvian Y chromosome genetic diversity. Specifically, the project aims to: (1) characterize Y chromosomal genetic diversity in Native Peruvian groups via intensive population sampling, (2) test for significant correlations between genetic diversity measures, on the one hand, and variables that may have shaped genetic structure of these native populations, including past demographic events, on the other, and (3) conduct these tests on both a regional (Peruvian / Andean) and continental (SouthAmerican) scale. The study focuses on the non-recombining component (NRY) of the chromosome to resolve the population genetic structure of Native Peruvian populations. Population affinity, level of genetic diversity and gene flow will be examined using population genetic analyses. Y chromosomal haplotypes will form the basis of these comparisons, and these will be constructed using combinations of relatively slow mutating Single Nucleotide Polymorphisms (SNPs) and faster mutating Short Tandem Repeats (STRs). Thus far, Dr. Lizarraga and V. Rubin have sampled over 100 individuals from 6 populations throughout diverse geographic areas and linguistic families for the purposes of this project.