Structure Formation in active Cytoskeletal Systems (B01)

细胞使用非平衡力来创建、维持和动态控制结构的形成过程。尽管对分子组成进行了详细的鉴定，但重建最小的活性物质系统仍然是一个重大挑战，它可以恢复生物功能，并允许识别潜在的物理原理。在本项目中，我们将重建活性微管囊泡，旨在设计一个最小的主动迁移系统，并通过重组复杂的肌动蛋白网络中的运输过程来阐明主动运输的基本原理。

Cells use non-equilibrium forces to create, sustain and dynamically control structure formation processes. Despite a detailed identification of molecular constituents, it still remains a major challenge to reconstruct minimal active matter systems, which recover biological functions and allowing the identification of the underlying physical principles. In the present project we will reconstitute active microtubule vesicles, aiming for the design of a minimal active migratory system and elucidate fundamental principles of active transport by reconstitution of transport processes in complex actin networks.