Structure, Reorganization Dynamics and Reactivity of Self Assembled Carbanionic Species

自组装碳负离子的结构、重组动力学和反应活性

• 批准号: 0315989
• 负责人: Gideon Fraenkel
• 金额: --
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0315989&HistoricalAwards=false
• 关键词: Structure; Reorganization; Dynamics; Reactivity; Self

With the support of the Organic Dynamics Program in the Chemistry Division, Professors Gideon Fraenkel at Ohio State University proposes to focus on carbanionic substances as revealed by the structure and behavior of selected categories of organolithium compounds. The objective is to correlate structures with the dynamics and mechanisms of their fast equilibrium reorganizations and their chemical behaviors. Structure will be investigated with X-ray crystallography and new NMR experiments while dynamic information will be obtained using proton, 13C, 6Li, 7Li and 15N NMR line shape analyses. DFT calculations will be used to analyze the results and help predict new interesting systems for possible future study. Model compounds have been designed to reveal specific aspects of structure and dynamics.The Organic and Macromolecular Chemistry Program in the Chemistry Division supports Professor Gideon Fraenkel at Ohio State University who will utilize many areas of chemistry including organic and organometallic synthesis, dynamic NMR, DFT calculations and X-ray crystallography to examine critical problems. Professor Fraenkel's have provided enhanced opportunities in the job market for women and members of other unrepresented groups who have participated in the research. Former students have entered both traditional and non-traditional fields. Dr. Fraenkel was PI of the REU site here 1997-2000 and he administered the department's undergraduate research program for six years. The REU program was particularly successful in recruiting talented students from traditionally black colleges. Professor Fraenkel's research is leading to a fundamental understanding of organolithium compounds and their use in reactions. Many groups from all over the country have consulted with the group on their synthetic problems involving organolithium compounds. For example, research results and consultations have benefited institutions such as Goodyear Tire and Rubber Co, researchers at Cornell University, and Merck Co.

在化学系有机动力学项目的支持下，俄亥俄州州立大学的吉迪恩·弗伦克尔教授建议将重点放在碳负离子物质上，如有机锂化合物的结构和行为所揭示的。目标是将结构与其快速平衡重组的动力学和机制及其化学行为相关联。结构将通过X射线晶体学和新的NMR实验进行研究，而动态信息将通过质子、13 C、6Li、7 Li和15 N NMR线形分析获得。DFT计算将用于分析结果，并帮助预测新的有趣的系统，为未来可能的研究。模型化合物的设计揭示了结构和动力学的特定方面。化学系的有机和大分子化学项目支持俄亥俄州州立大学的Gideon Fraenkel教授，他将利用许多化学领域，包括有机和有机金属合成，动态NMR，DFT计算和X射线晶体学来研究关键问题。Fraenkel教授的研究为参与研究的妇女和其他无代表群体的成员提供了更多的就业机会。以前的学生进入了传统和非传统领域。Fraenkel博士是1997-2000年REU网站的PI，他管理了该部门的本科研究项目六年。REU计划在从传统的黑人大学招募有才华的学生方面特别成功。Fraenkel教授的研究导致了对有机锂化合物及其在反应中的应用的基本理解。来自全国各地的许多团体就其涉及有机锂化合物的合成问题与该小组进行了磋商。例如，研究成果和咨询使固特异轮胎和橡胶公司、康奈尔大学的研究人员和默克公司等机构受益。