Oxidation of Alkene and Indole Substrates by Oxodiperoxomolybdenum . trialkyl\(aryl\)phosphine oxide complexes

氧化二过氧化钼对烯烃和吲哚底物的氧化。

• 批准号: 0316199
• 负责人: Leslie Jimenez
• 金额: --
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-15 至 2009-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0316199&HistoricalAwards=false
• 关键词: Oxidation; Alkene; Indole; Substrates; Oxodiperoxomolybdenum

The focus of this research involves the development of new chiral methods for epoxide production. Oxodipoxomolybdenum trialkyl\(aryl)\phosphine oxide complexes will be used to oxidize alkene and indole substrates. Both biphasic and homogeneous solvent systems will be employed and a number of chiral phosphine oxide ligands will be synthesized and tested for the ability to promote catalytic, chiral oxidation when used in concert with oxidizing agents such as hydrogen peroxide, t-butyl hydroperoxide and bis(trimethylsilyl) peroxide.With this Minority Career Advancement Award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Leslie S. Jimenez in the Department of Chemistry at Rutgers University, New Brunswick. Professor Jimenez will focus her work on developing methodology for the preparation of epoxides, three-member rings containing two carbons and one oxygen. The project provides an excellent venue for the training of both undergraduates and graduate students and the results of the research could have impact in the pharmaceutical and agricultural industries.

本研究的重点是开发新的手性环氧化物生产方法。 氧化二环氧钼三烷基\（芳基）\氧化膦配合物将用于氧化烯烃和吲哚底物。这两个两相和均相溶剂系统将被采用和一些手性氧化膦配体将被合成和测试的能力，以促进催化，手性氧化时，与氧化剂，如过氧化氢，叔丁基氢过氧化物和双（三甲基硅）过氧化物。与此少数民族职业发展奖，有机和大分子化学计划是支持博士的研究。希门尼斯在新不伦瑞克罗格斯大学化学系。 Jimenez教授将把工作重点放在开发制备环氧化物的方法上，环氧化物是含有两个碳和一个氧的三元环。 该项目为本科生和研究生的培训提供了一个很好的场所，研究结果可能会对制药和农业行业产生影响。