Oxidation of Alkene and Indole Substrates by Oxodiperoxomolybdenum . trialkyl\(aryl\)phosphine oxide complexes

本研究的重点是开发新的手性环氧化物生产方法。氧化二氧钼三烷基\（芳基）\膦氧化物配合物将用于氧化烯烃和吲哚底物。将采用双相和均相溶剂体系，并将合成一些手性氧化膦配体，并测试当与氧化剂（如过氧化氢、过氧化氢t-丁基和过氧化二（三甲基硅基））协同使用时促进催化性手性氧化的能力。新不伦瑞克罗格斯大学化学系Leslie S. Jimenez博士的研究得到了有机和大分子化学项目的支持。希门尼斯教授将专注于开发制备环氧化物的方法，环氧化物是含有两个碳和一个氧的三元环。该项目为本科生和研究生的培训提供了一个很好的场所，研究结果可能对制药和农业行业产生影响。

The focus of this research involves the development of new chiral methods for epoxide production. Oxodipoxomolybdenum trialkyl\(aryl)\phosphine oxide complexes will be used to oxidize alkene and indole substrates. Both biphasic and homogeneous solvent systems will be employed and a number of chiral phosphine oxide ligands will be synthesized and tested for the ability to promote catalytic, chiral oxidation when used in concert with oxidizing agents such as hydrogen peroxide, t-butyl hydroperoxide and bis(trimethylsilyl) peroxide.With this Minority Career Advancement Award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Leslie S. Jimenez in the Department of Chemistry at Rutgers University, New Brunswick. Professor Jimenez will focus her work on developing methodology for the preparation of epoxides, three-member rings containing two carbons and one oxygen. The project provides an excellent venue for the training of both undergraduates and graduate students and the results of the research could have impact in the pharmaceutical and agricultural industries.