Acquisition of a Hybrid Small/Macromolecule X-Ray Diffractometer System

获得混合型小/高分子 X 射线衍射仪系统

• 批准号: 0319176
• 负责人: Sean Parkin
• 金额: $ 46.13万
• 依托单位: University of Kentucky Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0319176&HistoricalAwards=false
• 关键词: Acquisition; Hybrid; Small; Macromolecule; Ray

With support from the Major Research Instrumentation (MRI) Program, Sean Parkin and colleagues at the University of Kentucky will purchase a hybrid small/macromolecule X-ray diffractometer system with a SMART CCD detector. The instrumentation will include a rotating anode dual source X-ray generator, k-axis goniometer, focusing optics and low-temperature apparatus. The PIs will investigate polymorphism, superstructures, absolute stereochemistry, highly reactive/unstable compounds, charge density analysis and protein structure. Faculty at numerous small institutions in the area will also have access at no charge. The X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of the molecule relative to the neighboring molecules. These studies will have an impact in a number of areas, including polymer sciences and biochemistry.

在主要研究仪器 (MRI) 计划的支持下，肯塔基大学的 Sean Parkin 及其同事将购买带有 SMART CCD 探测器的混合小/高分子 X 射线衍射仪系统。 该仪器将包括旋转阳极双源 X 射线发生器、k 轴测角仪、聚焦光学器件和低温设备。 PI 将研究多态性、超结构、绝对立体化学、高反应性/不稳定化合物、电荷密度分析和蛋白质结构。 该地区众多小型机构的教职员工也将可以免费访问。 X 射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于相邻分子的空间排列的准确信息。这些研究将对许多领域产生影响，包括高分子科学和生物化学。