SBIR Phase I: New Heat Flow Sensor Development for High Throughput Microcalorimeters

SBIR 第一阶段：用于高通量微量热计的新型热流传感器开发

• 批准号: 0319657
• 负责人: Edwin Lewis
• 金额: $ 10万
• 依托单位: Energetic Genomics Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0319657&HistoricalAwards=false
• 关键词: SBIR; Phase; New; Heat; Flow

This Small Business Innovation Research Phase I project will yield a new heat flow or differential temperature sensing technology that will fundamentally improve micro-calorimeters and other instruments that depend on temperature measurement or control. The activity will complete the detailed design and fabrication of a new type of heat flow sensor having 10 to 100 times greater sensitivity than currently available thermopile and Peltier devices. The new "Micro Fabricated Silicon Thermopile Sensor" employing patented technology will be optimized for use in a Differential Scanning Calorimeter designed specifically for the study of biopolymers in dilute solution. A DSC test platform will be constructed for the evaluation of prototype MFST sensors and the performance of the MFST-DSC will be compared to existing Bio-DSC instruments. High-throughput screening approaches are ubiquitous in the pharmaceutical industry as part of the drug discovery process. The new MFST sensor will be critical to the development of high throughput bio-calorimeters with sufficient sensitivity to address applications in drug discovery, diagnostics, cell screening, and other practical health care applications.

这个小型企业创新研究第一阶段项目将产生一种新的热流或温差传感技术，从根本上改善微量热计和其他依赖于温度测量或控制的仪器。 这项活动将完成一种新型热流传感器的详细设计和制造，其灵敏度比现有的热电堆和珀耳帖装置高10至100倍。 采用专利技术的新型“微制造硅热电堆传感器”将被优化用于差示扫描量热计，该差示扫描量热计专为研究稀溶液中的生物聚合物而设计。 一个DSC测试平台将被构建用于评估原型MFST传感器，并将MFST-DSC的性能与现有的Bio-DSC仪器进行比较。 作为药物发现过程的一部分，高通量筛选方法在制药行业中无处不在。 新型MFST传感器对于开发高通量生物量热仪至关重要，其具有足够的灵敏度，可用于药物发现、诊断、细胞筛选和其他实际医疗保健应用。