Conference: IX Oxford Conference on Modeling and Control of Breathing, Fall 2003, in Paris, France

许多动物的呼吸涉及运动活动的节律性循环，其持续时间、间隔和幅度可以调节。 理论和计算科学家的贡献增强了对通气这一重要生物学功能的分析，在一系列动物中对神经元、肌肉、心血管效应和呼吸组件的生物力学之间的潜在相互作用进行了建模。自1978年以来，三年一度的牛津呼吸建模和控制会议为呼吸生理学家，神经生物学家和建模者提供了一个独特的论坛，以交流思想，并介绍他们在理解节奏呼吸控制机制方面的最新发现。 这一著名的传统在当前的后基因组时代已经成熟，呼吸系统从基因到行为的内在复杂性要求协调一致地部署建模和实验方法，以阐明分子，细胞和系统水平上的呼吸控制机制。这次会议强调了实验方法和建模方法之间的协同作用，并对将这种“后基因组”视角整合到理解呼吸控制中增加了新的关注。该格式通过提供一个共同的论坛来介绍和讨论提交的贡献，最大限度地提高了来自不同领域的工作者之间的互动。会谈包括对人类和啮齿动物以外的哺乳动物的研究，甚至包括无脊椎动物。 本次会议的潜在影响是高，在促进实验学家和定量建模者之间的必要沟通，包括理论和计算方面的生理和行为。会议论文集将以同行评审的方式出版，以使其他对电机控制，机器人技术，生物工程和比较生理学等更广泛领域感兴趣的人能够获得结果。这次会议将对提高年轻研究人员在呼吸生理学和计算神经科学方面的兴趣和知名度产生影响，并且似乎可能导致新型的跨学科协作互动。来自NSF的资金将帮助学生，博士后和年轻的研究人员无法获得其他资金参加会议。

Breathing in many animals involves a rhythmic cycle of motor activity that can be modulated in its duration, intervals, and amplitude. Analysis of this vital biological function of ventilation has been enhanced by contributions from theoretical and computational scientists, modeling potential interactions among neurons, muscles, cardiovascular effects, and biomechanics of the components involved in breathing, in a range of animals. Since 1978 the triennial Oxford Conference on Modeling and Control of Breathing has offered a unique forum for respiratory physiologists, neurobiologists and modelers to exchange ideas and present their latest findings in understanding mechanisms of control of rhythmic breathing. This celebrated tradition has come of age in the current post-genomic era, where the intrinsic complexity of the respiratory system from genes to behavior calls for a concerted deployment of modeling and experimental approaches to elucidate mechanisms of respiratory control at the molecular, cellular and system levels. This time the conference emphasizes a synergy between experimental and modeling approaches, adding a new attention to integrating this 'post-genomic' perspective into understanding respiratory control. The format maximizes interactions between workers from different fields by providing a common forum for presentation and discussion of submitted contributions. The talks include work on mammals other than humans and rodents, and even include invertebrates. The potential impact of this conference is high in fostering needed communication between experimentalists and quantitative modelers, including theoretical and computational aspects with physiology and behavior. The conference proceedings will be published in a peer-reviewed volume to make results available to others interested in the broader fields of motor control, robotics, bioengineering, and comparative physiology. This conference will have an impact on raising the interest and visibility of young investigators in respiratory physiology and computational neuroscience, and it seems likely lead to new kinds of collaborative interdisciplinary interactions. Funding from NSF will help students, postdocs, and young researchers without access to other funding to attend the conference.