Generation and Description of Dendritic Morphology

IBN 0338556 NIH/NSF人脑项目PI：Ascoli，Giorgio生成和树突形态的描述该项目的总体目标是为完整和紧凑的树突形态描述提供一个框架。其核心思想是定义从实验微观重建中提取统计测量并使用这些分布随机生成虚拟神经元的算法。如果合成神经元与真实神经元在统计上无法区分，则算法及其参数构成可接受的完整描述。如果算法参数对应于简单的物理观测(例如，分支直径和长度)，则描述是直观的，并且可以提供对导致成熟树枝形态的机制和发展过程的洞察。这一持续研究计划的目标是将系统级和亚细胞级的解剖学和生物物理组件添加到形态描述中，并扩展、改进和分发实验数据、模型以及软件工具的模拟和分析。

IBN 0338556NIH/NSF Human Brain ProjectPI: Ascoli, GiorgioGeneration and Description of Dendritic MorphologyThe overall goal of this project is to provide a framework for the complete and compact description of dendritic morphology. The central idea is to define algorithms that extract statistical measures from experimental microscopic reconstructions and use these distributions to stochastically generate virtual neurons. If the synthetic neurons ate statistically indistinguishable from the real counterparts, the algorithms and their parameters constitute ac acceptable and complete description. If the algorithmic parameters correspond to simple physical observables (e.g. branch diameter and length) the description is intuitively accessible and may provide insights as to the mechanistic and developmental processes that lead to mature dendritic morphology. The goal of this continuing research proposal is to add system-level and subcellular-level anatomical and biophysical components to the morphological description, and to expand, improve, and distribute the experimental data, models, and the simulation and analysis of software tools.