Generation and Description of Dendritic Morphology

树突形态的生成和描述

• 批准号: 0338556
• 负责人: Giorgio Ascoli
• 金额: $ 25万
• 依托单位: National Institutes of Health
• 依托单位国家: 美国
• 项目类别: Interagency Agreement
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0338556&HistoricalAwards=false
• 关键词: Generation; Description; Dendritic; Morphology

IBN 0338556NIH/NSF Human Brain ProjectPI: Ascoli, GiorgioGeneration and Description of Dendritic MorphologyThe overall goal of this project is to provide a framework for the complete and compact description of dendritic morphology. The central idea is to define algorithms that extract statistical measures from experimental microscopic reconstructions and use these distributions to stochastically generate virtual neurons. If the synthetic neurons ate statistically indistinguishable from the real counterparts, the algorithms and their parameters constitute ac acceptable and complete description. If the algorithmic parameters correspond to simple physical observables (e.g. branch diameter and length) the description is intuitively accessible and may provide insights as to the mechanistic and developmental processes that lead to mature dendritic morphology. The goal of this continuing research proposal is to add system-level and subcellular-level anatomical and biophysical components to the morphological description, and to expand, improve, and distribute the experimental data, models, and the simulation and analysis of software tools.

IBN 0338556 NIH/NSF人脑项目PI：Ascoli，Giorgio树突形态的生成和描述该项目的总体目标是提供一个完整和紧凑的树突形态描述框架。 其中心思想是定义从实验微观重建中提取统计测量的算法，并使用这些分布来随机生成虚拟神经元。 如果合成神经元与真实的对应神经元在统计上不可区分，则算法及其参数构成可接受的完整描述。 如果算法参数对应于简单的物理可观察量（例如，分支直径和长度），则描述是直观可访问的，并且可以提供关于导致成熟树突形态的机制和发育过程的见解。 这项持续研究提案的目标是将系统级和亚细胞级解剖和生物物理组件添加到形态描述中，并扩展，改进和分发实验数据，模型以及软件工具的模拟和分析。