SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease

在生理稳态条件下和疾病状态下，免疫细胞的运输是免疫监视的关键先决条件。适当的免疫监视在哺乳动物的体内平衡中至关重要，因为它不仅能防御病原体的入侵，而且还能通过不断清除死亡细胞来保证组织的完整性。为了既有效又有效，免疫细胞的迁移和运输行为必须被精确控制并根据需要进行微调。由于免疫细胞的运输并不遵循统一的过程，这一关键任务变得更加复杂。事实上，不同类型的免疫细胞具有独特的机制，使它们能够追踪特定亚群的贩运路线，以便在各自的目标组织内完成各自的任务。迄今为止，控制和组织哺乳动物免疫细胞运输这一复杂过程的分子和细胞特征仍未完全了解。因此，CRC 914的任务是解剖在炎症、发育和疾病状态下调节不同白细胞亚群迁移反应的信号和机制。一个名为“白细胞贩运”的综合研究训练组在我们的科学努力的两侧。从长远来看，CRC 914旨在通过特异性和选择性地靶向已确定的不同白细胞亚群的迁移模式，促进急性和慢性感染性和非感染性炎症疾病治疗干预的创新概念的发展。

Trafficking of immune cells is a key prerequisite for immune surveillance under physiological steady state conditions and during disease states. Proper immune surveillance is of utmost importance in mammalian homeostasis as it ensures defense against pathogen intruders, but also because it guarantees tissue integrity through the continuous removal of dying cells. In order to be both functional and efficient, the migration and trafficking behavior of immune cells has to be precisely controlled and fine-tuned on demand. This critical task is complicated by the fact that trafficking of immune cells does not follow a uniform process. Indeed, different types of immune cells are rather endowed with unique machinery allowing them to chase subset-specific trafficking routes in order to fulfill their individual tasks within their individual target tissues. To date, the molecular and cellular signatures that control and organize this complex process of mammalian immune cell trafficking are still incompletely understood. It is therefore the mission of CRC 914 to dissect the signals and mechanisms that regulate the migratory responses of distinct leukocyte subsets during inflammation, development and in disease states. An Integrated Research Training Group entitled “Leukocyte Trafficking” flanks our scientific efforts. As a long-term perspective, CRC 914 aims to contribute to the development of innovative concepts for therapeutic interventions during acute and chronic infectious and non-infectious inflammatory diseases by specifically and selectively targeting the identified migratory patterns of distinct leukocyte subsets.