CAREER: Theoretical and Numerical Investigation of Stress-Regulated Growth and Remodeling of Soft Tissues

职业：软组织应力调节生长和重塑的理论和数值研究

• 批准号: 0348194
• 负责人: Jia Lu
• 金额: $ 39.93万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0348194&HistoricalAwards=false
• 关键词: CAREER; Theoretical; Numerical; Investigation; Stress

Living organs respond to mechanical load not only by deformation, but also by growth, resorption and structural remodeling. While the elasticity of soft tissues is relatively well-studied, the interaction between mechanical factors and adaptive growth remains poorly understood. The goal of the project is to gain understanding of coupled stress-growth motion through (1) developing and evaluating biomechanics models for stress-regulated growth and remodeling in vascular system; (2) developing finite element formulations for the simulation of coupled stress-growth motion; and (3) investigating the mechanical aspect of aneurysm growth and remodeling. The research will bring new dimensions into the biomechanical analysis of soft tissues. A better understanding of tissue adaptive behavior and the relation to physiological functions is expected to be obtained out of this research. The project plans to incorporate the research results into classroom teaching by introducing new teaching modules for continuum mechanics, computational mechanics and vascular mechanics courses. It also offers educational opportunities for graduate and undergraduate students to work on leading edge research projects.

生物器官对机械负荷的反应不仅表现为变形，还表现为生长、吸收和结构重塑。虽然软组织的弹性研究相对较好，但机械因素和适应性生长之间的相互作用仍然知之甚少。该项目的目标是通过(1)开发和评估血管系统中应力调节生长和重塑的生物力学模型；(2)开发用于模拟应力-生长耦合运动的有限元公式；以及(3)研究动脉瘤生长和重塑的力学方面，以了解应力-生长耦合运动。这项研究将为软组织的生物力学分析带来新的维度。这项研究有望对组织适应行为及其与生理功能的关系有更好的理解。该项目计划通过引入连续介质力学、计算力学和血管力学课程的新教学模式，将研究成果纳入课堂教学。它还为研究生和本科生提供从事前沿研究项目的教育机会。