CAREER: Pericyclic Reaction Cascades in the Synthesis of Complex Molecules

特劳纳教授正在探索周环反应化学的应用，特别是电环化和环加成的级联反应，以合成结构有趣的天然产物。Trauner教授正在研究抗疟萘醌的仿生分子内动态动力学分解策略，复杂植物代谢物rubioncolin a的简明仿生合成，以及连接三大类天然产物的多环二萜的统一方法。与这些研究工作相结合，Trauner教授正在开发一系列研究生课程，并将在本科化学课程中纳入现代可视化工具和实验方法。通过这个职业奖，有机和大分子化学项目支持加州大学伯克利分校化学系Dirk Trauner教授的教学和研究工作。特劳纳教授正在开发高效和新颖的方法来构建复杂的有机化学结构，为合成有希望的活性有机化合物提供必要的工具，但自然丰度不足，无法从自然来源中回收。通过开发不同教育水平的新课程和课程内容，Trauner教授正在为下一代化学家的有效教育做出贡献，这些化学家受过培训，能够解决具有挑战性的跨学科研究问题。

Professor Trauner is exploring the use of pericyclic reaction chemistry, particularly cascades of electrocyclizations and cycloadditions, in the synthesis of structurally intriguing natural products. Professor Trauner is pursuing a biomimetic intramolecular dynamic kinetic resolution strategy to antimalarial naphthoquinones, a concise biomimetic synthesis of the complex plant metabolite rubioncolin A, and a unified approach toward polycyclic diterpenes that links three major classes of these natural products. In conjunction with these research efforts, Professor Trauner is developing a series of graduate course offerings and will incorporate modern visualization tools and experimental approaches in the undergraduate chemistry curriculum.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the teaching and research efforts of Professor Dirk Trauner, of the Department of Chemistry at the University of California at Berkeley. Professor Trauner is developing efficient and novel methods for the construction of complex organic chemical structures, providing the tools needed for the synthesis of organic compounds of promising activity but insufficient natural abundance to permit recovery from natural sources. Through the development of new courses and course content at a variety of educational levels, Professor Trauner is contributing to the effective education of the next generation of chemists trained to tackle challenging interdisciplinary research problems.