CAREER: Pericyclic Reaction Cascades in the Synthesis of Complex Molecules

职业：复杂分子合成中的周环反应级联

• 批准号: 0348770
• 负责人: Dirk Trauner
• 金额: $ 58万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-15 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0348770&HistoricalAwards=false
• 关键词: CAREER; Pericyclic; Reaction; Cascades; Synthesis

Professor Trauner is exploring the use of pericyclic reaction chemistry, particularly cascades of electrocyclizations and cycloadditions, in the synthesis of structurally intriguing natural products. Professor Trauner is pursuing a biomimetic intramolecular dynamic kinetic resolution strategy to antimalarial naphthoquinones, a concise biomimetic synthesis of the complex plant metabolite rubioncolin A, and a unified approach toward polycyclic diterpenes that links three major classes of these natural products. In conjunction with these research efforts, Professor Trauner is developing a series of graduate course offerings and will incorporate modern visualization tools and experimental approaches in the undergraduate chemistry curriculum.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the teaching and research efforts of Professor Dirk Trauner, of the Department of Chemistry at the University of California at Berkeley. Professor Trauner is developing efficient and novel methods for the construction of complex organic chemical structures, providing the tools needed for the synthesis of organic compounds of promising activity but insufficient natural abundance to permit recovery from natural sources. Through the development of new courses and course content at a variety of educational levels, Professor Trauner is contributing to the effective education of the next generation of chemists trained to tackle challenging interdisciplinary research problems.

Trauner教授正在探索使用周环反应化学，特别是电环化和环加成的级联，在结构上有趣的天然产物的合成。Trauner教授正在寻求一种抗疟疾萘醌类化合物的仿生分子内动态动力学解析策略，一种复杂植物代谢物rubioncolin A的简明仿生合成，以及一种将这些天然产物的三个主要类别联系起来的多环二萜的统一方法。在这些研究工作的同时，Trauner教授正在开发一系列研究生课程，并将现代可视化工具和实验方法纳入本科化学课程。通过这项CAREER奖，有机和高分子化学项目支持了加州大学伯克利分校化学系Dirk Trauner教授的教学和研究工作。Trauner教授正在开发用于构建复杂有机化学结构的有效和新颖的方法，为合成具有有前途活性但天然丰度不足以从天然来源回收的有机化合物提供所需的工具。通过在各种教育水平上开发新课程和课程内容，Trauner教授正在为下一代化学家的有效教育做出贡献，这些化学家经过培训，能够解决具有挑战性的跨学科研究问题。