CAREER: Pericyclic Reaction Cascades in the Synthesis of Complex Molecules

特劳纳教授正在探索周环反应化学的应用，特别是电环化和环加成反应的级联反应，用于合成结构有趣的天然产物。特劳纳教授正在寻求一种仿生分子内动态动力学拆分策略来对抗疟疾的萘醌类化合物，一种对复杂的植物代谢物Rubioncolin A的简明仿生合成方法，以及一种连接这些天然产物三大类的多环二萜化合物的统一方法。与这些研究工作相结合，Trauner教授正在开发一系列研究生课程，并将现代可视化工具和实验方法纳入本科化学课程。凭借这一职业奖项，有机和高分子化学计划正在支持加州大学伯克利分校化学系Dirk Trauner教授的教学和研究努力。特劳纳教授正在开发高效和新颖的方法来构建复杂的有机化学结构，为合成活性良好但自然丰度不足的有机化合物提供所需的工具，从而能够从自然来源中回收。通过开发不同教育水平的新课程和课程内容，特劳纳教授正在为解决具有挑战性的跨学科研究问题而培训的下一代化学家的有效教育做出贡献。

Professor Trauner is exploring the use of pericyclic reaction chemistry, particularly cascades of electrocyclizations and cycloadditions, in the synthesis of structurally intriguing natural products. Professor Trauner is pursuing a biomimetic intramolecular dynamic kinetic resolution strategy to antimalarial naphthoquinones, a concise biomimetic synthesis of the complex plant metabolite rubioncolin A, and a unified approach toward polycyclic diterpenes that links three major classes of these natural products. In conjunction with these research efforts, Professor Trauner is developing a series of graduate course offerings and will incorporate modern visualization tools and experimental approaches in the undergraduate chemistry curriculum.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the teaching and research efforts of Professor Dirk Trauner, of the Department of Chemistry at the University of California at Berkeley. Professor Trauner is developing efficient and novel methods for the construction of complex organic chemical structures, providing the tools needed for the synthesis of organic compounds of promising activity but insufficient natural abundance to permit recovery from natural sources. Through the development of new courses and course content at a variety of educational levels, Professor Trauner is contributing to the effective education of the next generation of chemists trained to tackle challenging interdisciplinary research problems.