Stereochemistry and Chiroptics in Complex Organized Media: From Dyeing Crystals to Dyeing Crystalline Tissues

通过这项更新提案，有机和高分子化学计划继续支持华盛顿州西雅图的华盛顿大学化学系的BartKahr教授的工作。 该研究将建立在PI在先前资助的赠款期间建造的第一台成功的可见光圆形消光成像显微镜（CEIM）的基础上。 这台仪器将被重建和完善，具有高光学质量的组件，用于检测弱二向色性和散射。 有了这台仪器，混合晶体的图像将通过两种机制，固有的圆二色性和一个新的效果，发现了PI，称为旋光散射。 使用这种技术，PI将收集数据，以确定晶体生长的机制。新的CIEM仪器将适用于细胞生物学和材料科学中的大量问题。 吸附物与手性晶体表面的相互作用将通过使用CIEM收集界面处的对映选择性的直接光谱证据来研究。 PI在单晶研究中获得的经验将扩展到使用染色多晶材料的病理学和细胞生物学领域。 此外，这项研究将为学生提供晶体制造领域的宝贵培训，这是一项工作场所缺乏的技能。

With this renewal proposal the Organic and Macromolecular Chemistry Program continues its support for the work of Professor Bart Kahr of the Department of Chemistry at the University of Washington in Seattle, WA. The research will build on the PI's construction of the first successful visible light, circular extinction imaging microscope (CEIM) during the previously funded grant period. This instrument will be rebuilt and refined with components of high optical quality for the detection of weak dichroism and scattering. With this instrument, images of mixed crystals will be made via two mechanisms, intrinsic circular dichroism and a new effect, discovered by the PI, called optical rotatory scattering. Using this technique, the PI will collect data to determine the mechanisms of crystal growth. The new CIEM instrument will be applicable to a vast array of problems in cell biology and materials science. The interactions of adsorbates with chiral crystal surfaces will be investigated by collecting direct spectroscopic evidence of enantioselectivity at interfaces using the CIEM. The PI's experience, gained in studies of single crystals, will be extended to the areas of pathology and cell biology using dyed polycrystalline materials. In addition, the research will provide valuable training for students in the area of crystal fabrication, a skill that has been lacking in the workplace.