Physical Chemistry of Virus-like Particles

病毒样颗粒的物理化学

• 批准号: 0400363
• 负责人: Charles Knobler
• 金额: $ 69.1万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0400363&HistoricalAwards=false
• 关键词: Physical; Chemistry; Virus; like; Particles

In this award, supported by the Experimental Physical Chemistry and Theoretical and Computational Chemistry Programs of the Chemistry Division and the Molecular Biophysics Program of the Division of Molecular and Cellular Biosciences, Profs. Charles M. Knobler and William M. Gelbart of University of California, Los Angeles will conduct collaborative experimental and theoretical research on the physics of encapsulation of charged polymers in virus-like capsid containers . A variety of experimental techniques will be used, including traditional biochemical methods, as well as atomic force microscopy and light-scattering studies. The theoretical aspect of the work will involve bringing together a variety of traditional theoretical tools to bear on this difficult problem.The studies by Profs. Knobler and Gelbart should help to provide the kind of basic information necessary to understand the mechanics of encapsidation of viral RNA. In addition, the types of information obtained from this study should also be useful in understanding a variety of other biophysical processes, such as the formation of chromosomes, and the research should help to guide biomimetic design of drug-delivery vehicles. The students and postdoctoral fellows working with Profs. Knobler and Gelbart should benefit from participating in a unique, interdisciplinary effort.

该奖项由化学学部的实验物理化学和理论与计算化学项目以及分子与细胞生物科学部的分子生物物理项目资助。加州大学洛杉矶分校的Charles M. Knobler和William M. Gelbart将对在病毒样衣壳容器中封装带电聚合物的物理学进行实验和理论合作研究。将使用各种实验技术，包括传统的生化方法，以及原子力显微镜和光散射研究。这项工作的理论方面将包括汇集各种传统理论工具来解决这个难题。教授们的研究。Knobler和Gelbart应该有助于提供理解病毒RNA包衣机制所必需的基本信息。此外，从本研究中获得的信息类型也应该有助于理解各种其他生物物理过程，例如染色体的形成，并且该研究应该有助于指导药物传递载体的仿生设计。与教授一起工作的学生和博士后。Knobler和Gelbart应该从参与一项独特的跨学科努力中受益。