International Research Fellowship Program: Long-Term Effects of the Developmental Environment on the Immune Response in Ring-Necked Pheasants (Phasianus Colchicus)

国际研究奖学金计划：发育环境对环颈雉（Phasianus Colchicus）免疫反应的长期影响

• 批准号: 0404762
• 负责人: Jennifer Grindstaff
• 金额: --
• 依托单位: Grindstaff Jennifer L
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-15 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0404762&HistoricalAwards=false
• 关键词: International; Research; Fellowship; Program; Long

0404762GrindstaffThe International Research Fellowship Program enables U.S. scientists and engineers to conduct three to twenty-four months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad.This award will support a twenty-two-month research fellowship by Dr. Jennifer L. Grindstaff to work with Dr. Henrik G. Smith at Lund University on Sweden.Most research in ecological immunology assumes that developmental stress has only short-term effects on offspring immune function. This project tests this assumption in a population of ring-necked pheasants (Phasianus colchicus) by quantifying the immune response of offspring in adulthood after experimentally eliminating intestinal parasites in some individuals during ontogeny and/or during the maternal breeding period. The immune responses during the period of parasite manipulation are also measured to assess the effects of current condition on the immune response. Finally, parents and offspring are genotyped to determine the role of MHC genotype in the immune response to specific antigens. This research will contribute to our understanding of the role of development in modulating the adult phenotype and the influence of environmental versus genetic differences in determining the magnitude of the immune response.

0404762 Grindstaff国际研究奖学金计划使美国科学家和工程师能够在国外进行三到二十四个月的研究。 该计划的奖项提供了联合研究的机会，以及使用独特或互补的设施，专业知识和国外的实验条件。Grindstaff与Henrik G博士合作。生态免疫学的大多数研究都假设发育压力对后代的免疫功能只有短期的影响。 本项目在环颈雉（Phasianus colchicus）种群中测试这一假设，方法是在个体发育和/或母体繁殖期间实验性消除某些个体的肠道寄生虫后，量化成年期后代的免疫反应。 在寄生虫操作期间的免疫应答也被测量以评估当前条件对免疫应答的影响。 最后，父母和后代进行基因分型，以确定MHC基因型在对特定抗原的免疫应答中的作用。 这项研究将有助于我们了解的作用，在调节成人表型和环境与遗传差异的影响，在确定免疫反应的大小的发展。