Non-cellautonomous role of the endoribonuclease ENDU-2/ENDOU/PP11 in tumorigenesis and invasion (A06)
Non-cellautonomous role of the endoribonuclease ENDU-2/ENDOU/PP11 in tumorigenesis and invasion (A06)
核糖核酸内切酶 ENDU-2/ENDOU/PP11 在肿瘤发生和侵袭中的非细胞自主作用 (A06)
批准号：
166223730
负责人：
金额：
$0.0万
依托单位国家：
德国
项目类别：
Collaborative Research Centres
财政年份：
2010
资助国家：
德国
项目状态：
已结题
起止时间：
2009-12-31 至 2020-12-31
中文摘要
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英文摘要
A model for stem cell reprogramming and hyperproliferation by microenvironmental factors was established in C. elegans that additionally allows for studies of migration and invasion of tumor cells from their niche. The endoribonuclease ENDU-2 is sufficient for the induction of germline tumorigenesis and will be studied by a combination of biochemical and genetic experiments in C. elegans and human cell culture.
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