Collaborative Research: RUI-Studies of Antigen/Antibody Interactions with Nanoparticles

合作研究：RUI-抗原/抗体与纳米粒子相互作用的研究

• 批准号: 0406138
• 负责人: Caryn Seney
• 金额: $ 17.86万
• 依托单位: Mercer University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0406138&HistoricalAwards=false
• 关键词: Collaborative; Research; RUI; Studies; Antigen

Professors Caryn Seney of Mercer University and Robin Bright of Fort Valley State College are supported by the Analytical and Surface Chemistry Program to optimize surface enhanced Raman spectroscopy (SERS) signals from antibody/antigen interactions using mixed silver and gold nanoparticles. The new idea is to use gold nanoparticles to immobilize proteins without the structural degradation sometimes induced by silver nanoparticles, while the subsequent addition of silver provides enhancement of the SERS signal. This project links two undergraduate institutions in Georgia, separated by 30 miles, one (FVSC), an HBCU. Undergraduate students, including some from underrepresented groups, are being introduced to a timely combination of nanomaterials, spectroscopy, immunochemistry and bioanalyte detection. The project provides fundamental background for biosensor development.

美世大学的Caryn Seney教授和福特谷州立学院的Robin Bright教授得到了分析和表面化学项目的支持，使用混合的银和金纳米颗粒优化来自抗体/抗原相互作用的表面增强拉曼光谱（Sers）信号。 新的想法是使用金纳米颗粒来包裹蛋白质，而不会引起银纳米颗粒有时引起的结构降解，而随后加入的银提供了增强的Sers信号。该项目将格鲁吉亚的两所本科院校联系起来，它们相距30英里，其中一所（FVSC）是HBCU。 本科生，包括一些来自代表性不足的群体，正在被引入到纳米材料，光谱学，免疫化学和生物分析物检测的及时组合。 该项目为生物传感器的开发提供了基础背景。