Control of tumor cell proliferation, migration and invasion by SNAIL1-induced changes in Wnt and BMP pathway activity (B05)

SNAIL1 诱导的 Wnt 和 BMP 通路活性变化控制肿瘤细胞增殖、迁移和侵袭 (B05)

• 批准号: 166258318
• 金额: --
• 依托单位: Institut für Molekulare Medizin und Zellforschung
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/166258318?language=en
• 关键词: Control; tumor; cell; proliferation; migration

The project pursues the working-hypothesis that SNAIL1 hijacks Wnt and BMP signaling to stimulate EMT-associated gene expression in colorectal cancer, and will dissect the role of LEF1, a Wnt pathway effector, and of SMAD proteins, mediators of BMP signals, in the execution of EMT. Novel LEF1- and BMP-regulated genes will be identified and their impact on proliferation and invasion will be characterized.

该项目追求的工作假设，即SNAIL1劫持Wnt和BMP信号，以刺激EMT相关基因在结直肠癌中的表达，并将剖析LEF 1，Wnt通路效应器，和SMAD蛋白，BMP信号的介质，在EMT的执行中的作用。新的LEF1和BMP调节基因将被确定，其对增殖和侵袭的影响将被表征。