RUI: Mechanistic Studies of the Rhodium-Catalyzed Cyclization of ortho-Formyl Styrenes

本文研究的重点是过渡金属配合物催化烯烃的不对称氢化反应。此外，还将开发一种新发现的铑催化[4+2]环加成反应，生成氢萘和取代萘酚。通过这项本科院校研究（RUI）奖，有机和大分子化学项目支持东卡罗莱纳大学化学系Andrew T. Morehead博士的研究和教育活动。Morehead教授将致力于开发不对称合成吲哚酮的方法；在大量天然的和合成的有机体系中发现的结构单元。该项目将包括本科生和硕士生的培训，工作的更广泛影响将主要在该领域。

The focus of this research involves the asymmetric hydroacylation of alkenes catalyzed by transition metal complexes. In addition, a newly discovered rhodium-catalyzed [4+2] cycloaddition reaction leading to the production of hydronaphthalenes and substituted naphthols will be developed.With this Research in Undergraduate Institutions (RUI) award, the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. Andrew T. Morehead in the Department of Chemistry at East Carolina University. Professor Morehead will focus his work on developing methods for the asymmetric synthesis indanones; a structural unit found in a large number of natural and synthetically prepared organic systems. The project will include the training of undergraduates and masters level students and the broader impact of the work will be mainly in that area.