RUI: Mechanistic Studies of the Rhodium-Catalyzed Cyclization of ortho-Formyl Styrenes

RUI：铑催化邻甲酰基苯乙烯环化的机理研究

• 批准号: 0415484
• 负责人: Andrew Morehead
• 金额: $ 22.8万
• 依托单位: East Carolina University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0415484&HistoricalAwards=false
• 关键词: RUI; Mechanistic; Studies; Rhodium; Catalyzed

The focus of this research involves the asymmetric hydroacylation of alkenes catalyzed by transition metal complexes. In addition, a newly discovered rhodium-catalyzed [4+2] cycloaddition reaction leading to the production of hydronaphthalenes and substituted naphthols will be developed.With this Research in Undergraduate Institutions (RUI) award, the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. Andrew T. Morehead in the Department of Chemistry at East Carolina University. Professor Morehead will focus his work on developing methods for the asymmetric synthesis indanones; a structural unit found in a large number of natural and synthetically prepared organic systems. The project will include the training of undergraduates and masters level students and the broader impact of the work will be mainly in that area.

本研究的重点是过渡金属络合物催化的烯烃不对称氢酰化反应。此外，还将开发一种新发现的由铑催化的[4+2]环加成反应，导致氢化萘和取代的萘酚的产生。有了这项本科院校研究奖(RUI)，有机和高分子化学计划将支持东卡罗来纳大学化学系安德鲁·T·莫尔黑德博士的研究和教育活动。莫尔黑德教授将专注于开发不对称合成吲哚的方法，吲哚是一种结构单元，存在于大量天然和人工合成的有机体系中。该项目将包括对本科生和硕士研究生的培训，这项工作的更广泛影响将主要在这一领域。