Connectivity and function of regenerated neurons in the cerebral cortex – from transplantation to direct neuronal reprogramming (A06)

大脑皮层再生神经元的连接和功能â从移植到直接神经元重编程（A06）

• 批准号: 167578145
• 金额: --
• 依托单位: Institut für Physiologische Genomik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/167578145?language=en
• 关键词: Connectivity; function; regenerated; neurons; cerebral

In the previous funding period we have used a selective ablation model to show the appropriate integration of neurons transplanted from fetal cerebral cortex into the adult murine visual cortex. In the present project we aim first to move this approach towards more clinically relevant models such as traumatic brain injury also in older mice and examine myelination of the transplanted neurons, a key question as regenerating mature neurons fail to be myelinated. In the second project part we will examine the integration and axonal myelination of new neurons obtained by direct reprogramming from local reactive glial cells, based on the breakthrough in this approach after traumatic brain injury we achieved in the last funding period using the read-outs from in coll. with A08.

在之前的资助期内，我们使用了选择性消融模型来显示从胎儿大脑皮层移植到成年小鼠视觉皮层的神经元的适当整合。在目前的项目中，我们的目标首先是将这种方法应用于更临床相关的模型，如老年小鼠的创伤性脑损伤，并检查移植神经元的髓鞘形成，这是再生的成熟神经元无法髓鞘形成的关键问题。在第二个项目部分，我们将研究通过直接重编程从局部反应性神经胶质细胞获得的新神经元的整合和轴突髓鞘形成，这是基于我们在上一个资助期利用coll的读取结果在创伤性脑损伤后取得的突破。A08。