Purchase of a High Resolution ESI-TOF Mass Spectrometer

在化学研究仪器和设施：部门多用户仪器（CRIF：MU）计划的支持下，南佛罗里达大学化学系将获得一台具有高效液相色谱（HPLC）的高分辨率电喷雾飞行时间（ESI-TOF）质谱仪。这台质谱仪将加强各种研究项目，包括：（a）海洋天然产品的分离和定性;（B）发展有机合成方法及其在合成生物学上重要的天然产品中的应用;（c）作为β-发夹稳定剂的限制性二肽单元的定性;（d）新酰胺代谢物的生物合成;（e）生物合成。（e）新型N-硫醇化β-内酰胺的设计和合成;以及（f）新型纳米级自组装笼的研究。该工具将纳入高级“方法”课程和研究生“研究工具”课程。高分辨率质谱仪还将促进USF其他部门与地区工业和大学之间的合作。质谱（MS）是一种用于探测亲密结构细节并获得大量有机分子、生物有机分子和有机金属分子的分子组成的技术。它是发展最快、使用最广泛的分析仪器技术之一。该仪器将影响海洋天然产物、肽化学、合成有机和无机化学、生物化学、材料化学和纳米技术领域的研究。

With support from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation (CRIF:MU) Program, the Department of Chemistry at the University of South Florida will acquire a high-resolution electrospray time-of-flight (ESI-TOF) mass spectrometer with a high performance liquid chromatogram (HPLC). This mass spectrometer will enhance a variety of research projects including: (a) the isolation and characterization of marine natural products; (b) the development of organic synthetic methodologies and their application to the synthesis of biologically important natural products; (c) characterization of constrained dipeptide units as beta-hairpin stabilizers; (d) the biosynthesis of novel amide metabolites; (e) the design and synthesis of novel N-thiolated beta-lactams; and (f) the study of novel, nano-scale, self-assembled cages. The instrument will be incorporated into both a senior-level "Methods" course and a graduate-level "Tools of Research" course. The high-resolution mass spectrometer will also facilitate collaboration between other USF departments and area industries and universities.Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. It is one of the fastest growing and most widely used analytical instrumentation techniques. The instrument will impact research in the areas of marine natural products, peptide chemistry, synthetic organic and inorganic chemistry, biochemistry, materials chemistry, and nanotechnology.