CAREER: Roles of Transition Metals in Dioxygen Activation and Superoxide Scavenging

这个在无机，生物无机和有机化学计划的职业奖支持教授贾斯汀罗斯在约翰霍普金斯大学的工作，以探测O2与过渡金属通过氧同位素效应的测定的相互作用。 从自然丰度的O-16和O-18的比例的变化的测量将揭示在过渡金属试剂的分子氧的相互作用中发挥作用的热力学和动力学因素。 氧化还原过程中氧键的变化在工业氧化和O2作为能源的生物利用中是重要的。 将研究金属-O2加合物的性质，并收集电化学数据，以解决这些物种进行C-H和O-H氧化的能力。 对于电子、质子和氢原子转移反应，将探讨驱动力和速率之间的相关性。 一个针对巴尔的摩中学适龄女性的强化辅导计划将建立在与马里兰州科学中心有关的夏季讲习班的基础上。 经过两年以示范为中心的研讨会，第三年将专注于为科学中心制作一个生物技术展示。氧化过程在生物系统和工业环境中很重要。 元素氧与过渡金属配合物相互作用的机理与大规模化学和生物化学有关。 比较氧同位素的动力学和平衡分布将提供洞察力的键合变化，伴随着激活和纳入的氧到金属络合物和有机基板。

This CAREER award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Justine Roth at Johns Hopkins University to probe the interaction of O2 with transition metals via the determination of oxygen isotope effects. Measurements of the variation in O-16 and O-18 ratios from natural abundance will reveal thermodynamic and kinetic factors that play a role in the interaction of dioxygen with transition metal reagents. Changes in oxygen bonding during redox processes are important in industrial oxidations and in biological utilzation of O2 as an energy source. The properties of metal-O2 adducts will be investigated, and electrochemical data will be gathered to address the ability of these species to carry out C-H and O-H oxidations. Correlations between driving-force and rate will be explored for electron, proton and hydrogen atom transfer reactions. An intensive mentoring program for middle school aged females in Baltimore will build on summer workshops associated with the Maryland Science Center. After two years of centering the workshops on demonstrations, the third year will focus on crafting a biotechnology display for the science center.Oxidation processes are important in biological systems and in industrial settings. The mechanism of elemental dioxygen interacting with transition metal complexes is relevant to large scale chemistry and biochemistry. Comparing kinetic and equilibrium distributions of oxygen isotopes will provide insight into the bonding changes that accompany activation and incorporation of oxygen into metal complexes and organic substrates.