International Research Fellowship Program: Serotonergic Regulation of Neuroendocrine, Autonomic, and Behavioral Responses to Acute Stress: The Role of the Dorsomedial Hypothalamus

国际研究奖学金计划：神经内分泌、自主神经和行为对急性应激反应的血清素调节：下丘脑背内侧的作用

• 批准号: 0502379
• 负责人: Paul Gasser
• 金额: $ 15.39万
• 依托单位: Gasser, Paul J
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-15 至 2007-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0502379&HistoricalAwards=false
• 关键词: International; Research; Fellowship; Program; Serotonergic

0502379GasserThe International Research Fellowship Program enables U.S. scientists and engineers to conduct three to twenty-four months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad.This award will support a twenty-two-month research fellowship by Dr. Paul J. Gasser to work with Dr. Christopher A. Lowry at the University of Bristol in the United Kingdom.This research examines the regulation of neuroendocrine, autonomic, and behavioral components of the stress response by serotonin (5-hydroxytryptamine, 5-HT) actions in the rat dorsomedial hypothalamus (DMH), a nodal structure in the neural circuits mediating physiological and behavioral responses to stress. The project has two primary objectives, 1) to determine the effects of increases in extracellular 5-HT concentrations in the DMH on neuroendocrine, autonomic, and behavioral responses to stress and 2) to investigate the effects of the manipulations described above on signaling within neural circuits mediating physiological and behavioral aspects of the response to stress. The Pis will examine regulation of the magnitude and duration of the acute stress response. This is a fundamental question in vertebrate stress physiology, and has implications for human health, as insufficient control of the stress response has been implicated in human physiological and behavioral disorders, including hypertension, asthma, panic disorder, and major depression. These studies will be conducted in collaboration with Dr. Lowry, an international expert on the neuroanatomy of brain serotonergic systems and their roles in the regulation of behavioral responses to stress. Dr. Lowry's laboratory is part of the Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology (HW-LINE), a state-of-the-art research facility which is home to a group of international experts in neural and endocrine regulation of physiology and behavior.

[502379]国际研究奖学金计划使美国科学家和工程师能够在国外进行三到二十四个月的研究。该计划的奖励为联合研究提供了机会，并利用独特或互补的设施、专业知识和国外的实验条件。该奖项将支持Paul J. Gasser博士与英国布里斯托尔大学的Christopher a . Lowry博士进行为期22个月的研究。本研究探讨了大鼠下丘脑背内侧（DMH）中5-羟色胺（5-羟色胺，5-HT）作用对应激反应的神经内分泌、自主神经和行为成分的调节。DMH是神经回路中的一个节点结构，介导应激的生理和行为反应。该项目有两个主要目标：1)确定DMH中细胞外5-HT浓度增加对神经内分泌、自主神经和应激行为反应的影响；2)研究上述操作对神经回路中介导应激生理和行为反应的信号传导的影响。Pis将检查急性应激反应的幅度和持续时间的调节。这是脊椎动物应激生理学中的一个基本问题，对人类健康也有影响，因为对应激反应的控制不足与人类的生理和行为障碍有关，包括高血压、哮喘、恐慌症和重度抑郁症。这些研究将与Lowry博士合作进行，Lowry博士是脑血清素能系统的神经解剖学及其在调节压力行为反应中的作用方面的国际专家。Lowry博士的实验室是Henry Wellcome综合神经科学和内分泌学实验室（HW-LINE）的一部分，这是一个最先进的研究设施，是一群国际专家在生理和行为的神经和内分泌调节方面的家。