SGER: The Structure of Water at Biological Interfaces

SGER：生物界面处的水结构

• 批准号: 0509623
• 负责人: Anders Nilsson
• 金额: --
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0509623&HistoricalAwards=false
• 关键词: SGER; Structure; Water; Biological; Interfaces

This exploratory research project will investigate the nature of solid-water interfaces that are essential for many processes related to biomaterials and biological function. It will explore the potential for applying new tools such as x-ray spectroscopic techniques utilizing synchrotron radiation for studying self assembled monolayers (SAM) on gold as functionalized surfaces with different chemical end groups that interact with water differently. Probing the hydrogen-bonding network in water using x-ray absorption spectroscopy will reveal how water restructures itself around different chemical terminations of the SAM overlayer. The underlying question to be addressed is how biological water differs in comparison with bulk water, and how it affects the functioning of different biomaterials. Several fundamental questions of an interdisciplinary nature involving material science, chemistry and biology will be addressed. Understanding the solid-water interface is essential for many processes related to biomaterials and biological function. Functionalizing surfaces with biologically active molecules has important technological applications relevant to biomaterials, biocatalysis, biocompatibility and bioelectronics and biosensors.

该探索性研究项目将研究固水界面的性质，该界面对于与生物材料和生物功能相关的许多过程至关重要。它将探索应用新工具的潜力，例如利用同步加速器辐射的 X 射线光谱技术来研究金上的自组装单分子层 (SAM)，作为具有不同化学端基的功能化表面，这些端基与水的相互作用不同。使用 X 射线吸收光谱探测水中的氢键网络将揭示水如何围绕 SAM 覆盖层的不同化学末端重组自身。要解决的根本问题是生物水与散装水相比有何不同，以及它如何影响不同生物材料的功能。将解决涉及材料科学、化学和生物学的几个跨学科基本问题。了解固水界面对于与生物材料和生物功能相关的许多过程至关重要。用生物活性分子功能化表面具有与生物材料、生物催化、生物相容性以及生物电子学和生物传感器相关的重要技术应用。