SBIR Phase I: Chiral, Carbohydrate Polyethers for Robust, High Resolution, Pharmaceutical Separations

这个小企业创新研究第一阶段项目将开发一种新的碳水化合物聚醚手性色谱，从淀粉生产的左旋葡萄糖开始。在十大畅销药物中，有九种药物的活性成分是手性的。（2-3）-聚醚是独特的，因为它们具有多个连续的手性中心，这些手性中心可以被操纵以形成所需的中间体，具有无与伦比的光学完整性和所有已知分子中最高密度的官能团。药物制造商寻求具有高和扩展的手性选择性、高负载容量和耐受宽范围的移动的相的能力的新的手性固定相。为了满足这一需求，将合成环氧单体并聚合成用于对映体液相色谱的100%立体特异性手性固定相。这种聚醚相将应用于二氧化硅载体，并由领先的色谱设备制造商进行评估。该项目的商业应用将主要是生产对映体纯药物。拟议工作的进一步影响将扩展到药物纯化，糖分离，选择性环氧化和一系列生物精炼产品的受控聚合。

This Small Business Innovation Research Phase I project will develop a new class of carbohydrate polyethers for chiral chromatography, by starting with levoglucogan produced from starch. In nine out of the top ten selling drugs, the active ingredient is chiral. The (2-3)-polyethers are unique because they have multiple contiguous chiral centers, which can be manipulated to form desired intermediates, with unparalleled optical integrity and the highest density of functional groups of all known molecules. Drug manufacturers seek new chiral stationary phases with high and extended chiral selectivity, high loading capacity, and ability to tolerate a wide range of mobile phases. To meet this need, epoxide monomers will be synthesized and polymerized into a 100% stereo specific chiral stationary phase for liquid chromatography of enantiomers. This polyether phase will be applied to silica supports and evaluated by leading chromatography equipment manufacturers. The commercial application of this project will primarily be in the manufacture of enantiomerically pure pharmaceuticals. Further impact of the proposed work will extend to drug purification, sugar separations, selective epoxidation, and controlled polymerization for a range of bio-refinery products.