Fragmentation Of Biomolecules By Ionizing Radiation: Theoretical And Computaional Studies

电离辐射对生物分子的裂解：理论和计算研究

• 批准号: 0513386
• 负责人: Yngve Ohrn
• 金额: $ 36万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0513386&HistoricalAwards=false
• 关键词: Fragmentation; Biomolecules; Ionizing; Radiation; Theoretical

Yngve Ohrn and Erik Deumens of the University of Florida are supported by an award from the Theoretical and Computational Chemistry program within the Division of Chemistry for research into the mechanism of material damage, particularly in biological materials, caused by energetic radiation of charged particles such as electrons, protons, and alpha particles. They are modifying their original technique known as Electron Nuclear Dynamics, or END, to allow the study of processes involving the attack of free electrons on large molecules. The damage by primary projectiles to cellular material is of significance for the formation of intermediate species, such as radicals, ions, and electrons, that can, via a number of mechanisms be involved in reactive processes to seriously damage DNA and other biomolecules. The work is, thus, having a broader impact on our understanding of the effects of ionizing radiation on living systems.

佛罗里达大学的Yngve Ohrn和Erik Deumens获得了化学系理论与计算化学项目的奖项，以支持他们对材料损伤机制的研究，特别是在生物材料中，由带电粒子（如电子、质子和α粒子）的高能辐射引起的损伤。他们正在修改他们的原始技术，即电子核动力学（END），以允许研究涉及自由电子对大分子攻击的过程。初级弹丸对细胞物质的损伤对中间物质的形成具有重要意义，如自由基、离子和电子，它们可以通过多种机制参与反应过程，严重损害DNA和其他生物分子。因此，这项工作对我们理解电离辐射对生命系统的影响有着更广泛的影响。