Fragmentation Of Biomolecules By Ionizing Radiation: Theoretical And Computaional Studies

佛罗里达大学的Yngve Ohrn和Erik Deumens获得了化学系理论和计算化学项目的奖项支持，用于研究由带电粒子（例如电子、质子和α粒子）的高能辐射引起的材料损伤机制，特别是生物材料。他们正在修改他们的原始技术，称为电子核动力学，或END，以允许研究涉及自由电子攻击大分子的过程。初级射弹对细胞物质的损伤对于中间物质（例如自由基、离子和电子）的形成具有重要意义，所述中间物质可以通过许多机制参与反应过程以严重损伤DNA和其他生物分子。因此，这项工作对我们理解电离辐射对生命系统的影响具有更广泛的影响。

Yngve Ohrn and Erik Deumens of the University of Florida are supported by an award from the Theoretical and Computational Chemistry program within the Division of Chemistry for research into the mechanism of material damage, particularly in biological materials, caused by energetic radiation of charged particles such as electrons, protons, and alpha particles. They are modifying their original technique known as Electron Nuclear Dynamics, or END, to allow the study of processes involving the attack of free electrons on large molecules. The damage by primary projectiles to cellular material is of significance for the formation of intermediate species, such as radicals, ions, and electrons, that can, via a number of mechanisms be involved in reactive processes to seriously damage DNA and other biomolecules. The work is, thus, having a broader impact on our understanding of the effects of ionizing radiation on living systems.