Acquisition of a Multifunctional Imaging System for Molecular Life Science Research and Teaching

获取用于分子生命科学研究和教学的多功能成像系统

• 批准号: 0519716
• 负责人: Michael Reagan
• 金额: $ 2.86万
• 依托单位: Saint John's University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0519716&HistoricalAwards=false
• 关键词: Acquisition; Multifunctional; Imaging; System; Molecular

A grant has been awarded to St. John's University under the direction of Dr. Michael Reagan for partial support of the acquisition of a multifunctional imaging instrument for molecular biological investigations. This instrument is extremely versatile and will be used for the detection of nucleic acids (DNA and RNA) and proteins in a number of different investigations. The goal of this project is to enhance the ability of faculty and students at St. John's University and the College of St. Benedict to perform molecular life science experiments in both collaborative student/faculty research projects and in labs associated with classes. The instrument is crucial to a number of collaborative student/faculty investigations. These include studies a) of how damage to DNA affects transcription, b) investigation of the role of a particular protein, called phosphatase 1, in the formation and maintenance of blood vessels in the retina, c) studying the structure of short pieces of DNA (oligonucleotides) as well as in studies of the human enzyme called adipocyte acid phosphatase, found in adipose (fat) cells, and d) studies of the metabolic adaptations of a variety of different organisms to changes in growth conditions such as temperature and diet. These projects all address important biological problems of current interest. This multifunctional imager enhances the undergraduate research capabilities at the College of St. Benedict (CSB), a college for women and St. John's University (SJU), a college for men; two institutions that have a coordinate relationship and share a common curriculum with joint classes and departments. The instrument will be used by faculty and students in the Biology and Chemistry departments for collaborative research, and will be used in at least six undergraduate classes enrolling students with majors in Biology, Chemistry, Biochemistry, and Natural Science. Acquisition of this instrument will strengthen the research infrastructure of these departments by expanding the ability to visualize and analyze nucleic acids and proteins using a wide variety of techniques. In addition, this instrument will help the Biology and Chemistry departments continue to be successful at attracting and graduating women and American multicultural students by increasing the opportunities of students to participate in modern molecular biological research. This instrument will be a resource for the entire central Minnesota region; for example, faculty and students at the nearby St. Cloud State University will also be users of the instrument.

在Michael Reagan博士的指导下，向圣约翰大学提供了一笔赠款，用于部分支助购置一台用于分子生物学研究的多功能成像仪器。 该仪器是非常通用的，将用于检测核酸（DNA和RNA）和蛋白质在许多不同的调查。 本项目的目标是提高圣约翰大学和圣本尼迪克特学院的教师和学生在学生/教师合作研究项目和与课程相关的实验室中进行分子生命科学实验的能力。该仪器是至关重要的一些合作的学生/教师的调查。 这些研究包括a）DNA损伤如何影响转录，B）研究一种称为磷酸酶1的特定蛋白质在视网膜血管形成和维持中的作用，c）研究DNA短片段的结构（寡核苷酸）以及在脂肪细胞中发现的称为脂肪细胞酸性磷酸酶的人类酶的研究中，以及d）研究各种不同生物体对温度和饮食等生长条件变化的代谢适应性。 这些项目都涉及当前感兴趣的重要生物学问题。这款多功能成像仪增强了圣本尼迪克特学院（CSB）和圣约翰大学（SJU）的本科生研究能力，这两所大学具有协调关系，并通过联合班级和部门共享共同课程。 该仪器将用于教师和学生在生物和化学部门的合作研究，并将用于至少六个本科班招收学生在生物，化学，生物化学和自然科学专业。 该仪器的获得将通过扩大使用各种技术可视化和分析核酸和蛋白质的能力来加强这些部门的研究基础设施。 此外，该仪器将帮助生物和化学部门继续成功地吸引和毕业的妇女和美国多元文化的学生，增加学生参与现代分子生物学研究的机会。 该仪器将成为整个明尼苏达州中部地区的资源;例如，附近的圣克劳德州立大学的教师和学生也将是该仪器的用户。