CRC: Chemical Approaches to Glial-Neuronal Networks

CRC：胶质神经元网络的化学方法

• 批准号: 0526693
• 负责人: Rustem Ismagilov
• 金额: --
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0526693&HistoricalAwards=false
• 关键词: CRC; Chemical; Approaches; Glial; Neuronal

Irving R. Epstein (Brandeis University), Rustem F. Ismagilov (University of Chicago), Anna Lin (Duke University) and Jonathan Sweedler (University of Chicago) are jointly supported to study the chemical processes involved in glial-neuronal signaling. The collaborative project includes fabrication of topologically well-defined networks of microchannels to support neuronal and neuron-glial networks, time-resolved imaging of the calcium levels in both neurons and glial cells of rat hippocampus cultures, specific stimulation of spatially and temporally defined glial cells using microfluidic tools, advanced data analysis and modeling. Recent research suggests that glial cells are actively involved in chemical communication with and between neurons and other glia. Goals of this project include a better understanding of the role of glial cells in individual synapses and in neural networks, elucidation of the interaction between the network topology and the dynamics of individual elements (cells), and the development and evaluation of methods that can be applied to the analysis of complex chemical and biological networks. This project is funded through the Collaborative Research in Chemistry Program (CRC) and provides outstanding opportunities for undergraduate, graduate and postdoctoral students to acquire knowledge and skills in neurochemistry and bioanalytical chemistry.

布兰迪斯大学的欧文·R·爱泼斯坦、芝加哥大学的鲁斯特·F·伊斯马吉洛夫、杜克大学的安娜·林和芝加哥大学的乔纳森·斯威德勒共同研究了神经胶质细胞信号传递的化学过程。该合作项目包括构建支持神经元和神经元-神经胶质网络的拓扑定义良好的微通道网络、对大鼠海马神经元和神经胶质细胞培养中钙水平的时间分辨成像、使用微流体工具对空间和时间定义的神经胶质细胞进行特定刺激、高级数据分析和建模。最近的研究表明，神经胶质细胞积极参与神经元和其他神经胶质细胞之间的化学交流。该项目的目标包括更好地了解神经胶质细胞在单个突触和神经网络中的作用，阐明网络拓扑结构和单个元件(细胞)的动力学之间的相互作用，以及开发和评估可应用于复杂化学和生物网络分析的方法。该项目由化学合作研究计划(CRC)资助，为本科生、研究生和博士后学生提供了获取神经化学和生物分析化学知识和技能的绝佳机会。