Graphene biosensors

化学稳定性、低电噪声、生物相容性和优异的电子性能等特性的独特组合使石墨烯成为生物传感和生物电子应用的非常合适的候选者。该项目旨在开发基于石墨烯的生物传感器应用平台。特别是，我们将探索在需要电气和电化学传感的应用中使用高质量，大面积石墨烯。为此，该提案的部分目标是i）用于高质量石墨烯层的CVD生长和转移技术，ii）展示高性能的石墨烯装置的示范，iii）石墨烯/电解质界面的研究，iv）通过化学改性和经由与衬底的相互作用控制石墨烯性质和功能，以及v）超灵敏纳米级石墨烯传感器的开发。本提案中计划的活动分为两部分。第一个（Cattani-Schotz/Stutzmann小组）专注于制备高质量的石墨烯以及石墨烯表面的化学功能化。另一个（Garrido小组）专注于纳米级石墨烯器件（溶液门控FET和电极）阵列的制造和表征，以及石墨烯/水界面的电化学和电学性质的研究。总之，该项目旨在开发用于制备石墨烯生物传感器的技术和专有技术，为石墨烯的不同且极具前景的应用领域铺平道路。

The unique combination of properties like chemical stability, low level of electrical noise, biocompatibility, and excellent electronic performance, makes graphene a very suitable candidate for biosensing and bioelectronic applications. This project aims at the development of a graphene-based platform for biosensor applications. In particular, we will explore the use of high quality, large area graphene in applications requiring electrical and electrochemical sensing. To this end, the partial objectives of this proposal are i) the CVD growth and transfer technology for high quality graphene layers, ii) the demonstration of graphene devices exhibiting high performance, iii) the study of the graphene/electrolyte interface, iv) the control of graphene properties and functionality through chemical modifications and via interactions with substrates, and v) the development of ultra-sensitive nanoscale graphene sensors. The activities planned within this proposal are divided in two parts. The first (Cattani-Schotz/Stutzmann group) focuses on the preparation of high quality graphene together with the chemical functionalization of graphene surfaces. The other (Garrido group) focuses on the fabrication and characterization of arrays of nanoscale graphene devices (solution-gated FETs and electrodes), as well as the investigation of the electrochemical and electrical properties of the graphene/water interface. In summary, this project aims at the development of the technology and know-how for the preparation of graphene biosensors, paving the way for a different and highly promising field of applications for graphene.