Tissue specific regulation of gene expression

基因表达的组织特异性调控

• 批准号: DP0984701
• 负责人: Prof John Pimanda
• 金额: $ 19.26万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-03-01 至 2012-03-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0984701
• 关键词: Tissue; specific; regulation; gene; expression

Despite the polarized public debate concerning the use of stem cells for tissue regeneration, fundamental questions relating to the identity and hierarchy of these cells remain unanswered. The benefit to Australia will be scientific in terms of providing an understanding of how stem and progenitor cells integrate transcriptional control systems during differentiation and the networks that are involved. This is fundamental to the future isolation and manipulation of these stem cell types to benefit the community. The work will also provide postgraduate students with training in state of the art genomic techniques and in the interface between bioinformatics and experimental science.

尽管关于使用干细胞进行组织再生的公众辩论两极分化，但与这些细胞的身份和层级相关的基本问题仍然没有得到回答。这对澳大利亚的好处将是科学的，因为它提供了对干细胞和祖细胞如何在分化过程中整合转录控制系统以及涉及的网络的理解。这对于未来分离和操纵这些类型的干细胞以造福于社区是至关重要的。这项工作还将为研究生提供最先进的基因组技术以及生物信息学和实验科学之间的接口方面的培训。