Mechanistic Studies of Nucleotide Reactivity

核苷酸反应性的机理研究

• 批准号: 0543038
• 负责人: Jeehiun Lee
• 金额: $ 39.5万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0543038&HistoricalAwards=false
• 关键词: Mechanistic; Studies; Nucleotide; Reactivity

With this new award, the Organic and Macromolecular Chemistry Program supports the work of Professor Jeehiun K. Lee of the Chemistry Department at Rutgers University, New Brunswick, NJ. This research will broaden understanding of nucleotide chemistry through gas phase mass spectrometric and theoretical quantum mechanical studies. The gas phase acidity and proton affinity of natural nucleic acid bases and their derivatives will be explored in order to understand their fundamental reactivities. The inherent electronic, structural, and reactive properties of nucleic acids are of considerable fundamental interest and critical to understanding the role of these species as substrates in enzyme reactions and in DNA binding events. A combination of experiment and theory, ranging from mass spectrometry to organic synthesis to different levels of calculations, will be used in these studies. The research will promote teaching, training and learning through direct research experiences for undergraduates and graduates. The results of the proposed research will be integrated into a physical organic chemistry course providing examples of the ways in which physical methods can uncover the reactivity of biochemical molecules and contribute to the solution of important problems at the interface of chemistry and biology.

有了这个新的奖项，有机和高分子化学计划支持教授Jeehiun K。他是新泽西州新玩法罗格斯大学化学系的Lee博士。 这项研究将通过气相质谱和理论量子力学研究拓宽对核苷酸化学的理解。 天然核酸碱基及其衍生物的气相酸性和质子亲合性将被探索，以了解它们的基本反应性。 核酸固有的电子，结构和反应特性是相当大的根本利益和关键的理解这些物种的作用，在酶反应和DNA结合事件的底物。实验和理论的结合，从质谱到有机合成到不同层次的计算，将用于这些研究。 该研究将通过本科生和研究生的直接研究经验促进教学，培训和学习。 拟议的研究结果将被整合到一个物理有机化学课程提供的方式，其中物理方法可以揭示生物化学分子的反应性，并有助于在化学和生物学的接口的重要问题的解决方案的例子。