CAREER: Catalytic Aldimine Coupling: A Versatile Carbon-Carbon Bond Forming Reaction

本研究项目针对多种分子结构，包括碳环、杂环、大环、二聚体、配体、低聚物、共轭聚合物和非共轭聚合物，开发了氰化物催化的乙二胺偶联反应。将探索用替代催化剂替代氰化物的可能性，提供与环境和分子化学模块和课程计划开发的可持续性(绿色化学)重点的联系。在有机和高分子化学项目这一职业奖项的支持下，德克萨斯农工大学化学系的斯蒂芬·A·米勒教授正在探索一系列独特的由氰化物催化的反应。这种反应化学为合成许多新的有机产品提供了希望，潜在的应用包括制药、有机染料和均相催化等领域。在效率和催化方面，简单的两原子氰离子是值得注意的，特别是与高度工程化和昂贵的贵金属催化剂相比。效率和催化的概念也是米勒教授教育活动中不可或缺的一部分。通过一门关于环境分子观点的课程，德克萨斯州的高中教师和学生可以接触到环境化学主题，包括催化的原理、分支和普遍性，催化是绿色化学的12条原则之一。关于环境化学的写作课程为学生提供了科学和可持续发展跨学科性质的额外经验。

This research project addresses the development of a cyanide-catalyzed aldimine coupling reaction, targeting a number of molecular structures, including carbocycles, heterocycles, macrocycles, dimers, ligands, oligomers, and conjugated as well as non-conjugated polymers. The potential replacement of cyanide by alternate catalysts will be explored, providing a link to the sustainability (green chemistry) focus of the environmental and molecular chemistry modules and courses planned for development.With the support of this CAREER award from the Organic and Macromolecular Chemistry Program, Professor Stephen A. Miller, of the Department of Chemistry at Texas A&M University, is exploring a unique set of reactions catalyzed by cyanide. This reaction chemistry offers promise for the generation of many novel organic products, with potential applications including the areas of pharmaceuticals, organic dyes, and homogeneous catalysis. In the context of efficiency and catalysis, the simple, two-atom cyanide anion is remarkable, especially when compared to highly engineered and expensive precious metal catalysts. The concepts of efficiency and catalysis are also integral to the educational activities of Professor Miller. Through a course on a Molecular View of the Environment, high school teachers and students across the state of Texas are exposed to environmental chemistry topics, including the principles, ramifications, and ubiquity of catalysis, one of the 12 Principles of Green Chemistry. A writing course on Environmental Chemistry provides additional experience for students in the interdisciplinary nature of science and sustainability.