Dynamics of the Human Thyroid: Towards Clinical Applications

人类甲状腺的动力学：走向临床应用

• 批准号: 0556081
• 负责人: Yossi Chait
• 金额: --
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0556081&HistoricalAwards=false
• 关键词: Dynamics; Human; Thyroid; Towards; Clinical

AbstractThe thyroid, the largest gland in the endocrine system, secretes hormones that regulate homeostatic functions within the body and promote normal growth and development. In recent years, great strides have been made in identifying chemical signal pathways within the thyroid. Based upon recent molecular-level discoveries and clinical observations, this team has engineered a detailed computational model of the thyroid gland. Motivated by this model's development and confirmation, the main goal of the proposed research is to understand the thyroid's fundamental dynamics and to translate this understanding into therapeutic protocols for treating thyroid dysfunction. Examples of the proposed research include: 1) Understanding the dynamic of thyroid enlargement (goiter), 2) Analyzing the effects of drugs and environmental contaminants on thyroid hormone secretion, and 3) Improving radioactive iodine treatment of Grave's disease. The intellectual merit of this work is centered upon coordination of computational modeling, dynamical systems analysis, and clinical experience. The broader impact of the proposed research has short and long term implications: (i) improving diagnosis power (early intervention), (ii) improving treatment protocols (Grave's disease and hormone replacement), and (iii) enabling enhanced testing/screening of pharmaceuticals (mimic, enhance, diminish or block hormone actions).

甲状腺是内分泌系统中最大的腺体，它分泌的激素调节机体内环境的平衡，促进正常的生长和发育。 近年来，在识别甲状腺内的化学信号通路方面取得了很大进展。基于最近的分子水平发现和临床观察，该团队设计了一个详细的甲状腺计算模型。 受该模型的开发和确认的启发，拟议研究的主要目标是了解甲状腺的基本动力学，并将这种理解转化为治疗甲状腺功能障碍的治疗方案。 建议的研究包括：1）了解甲状腺肿大（甲状腺肿）的动态，2）分析药物和环境污染物对甲状腺激素分泌的影响，3）改进放射性碘治疗格雷夫斯病。这项工作的智力价值集中在计算建模，动力系统分析和临床经验的协调。拟议研究的更广泛影响具有短期和长期影响：（i）提高诊断能力（早期干预），（ii）改善治疗方案（格雷夫斯病和激素替代），以及（iii）能够增强药物的测试/筛选（模拟，增强，减少或阻断激素作用）。