Molecular signals that regulate the regenerative properties of intestinal epithelial cells

调节肠上皮细胞再生特性的分子信号

• 批准号: FT0991472
• 负责人: Dr Nick Barker
• 金额: --
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-07-01 至 2010-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT0991472
• 关键词: Molecular; signals; regulate; regenerative; properties

Most cancer deaths are due to the cancer spreading to other organs. Cancer is much more difficult to treat once it has spread to other organs in the body where the cancer cells can exist in a dormant state. Dormant cancer cells evade conventional anticancer treatment and can remain dormant for a very long time before they change back to a 'tumour-growing' state. An understanding of how the cancer initiating (stem cell) property of tumour cells is maintained offers potential novel avenues to eliminate persistent cancer cells. This knowledge will ultimately lead to better management and treatment of cancer, and increase survival. An understanding of stem cell behaviour is also central to the control of degenerative conditions.

大多数癌症死亡是由于癌症扩散到其他器官。一旦癌症扩散到身体的其他器官，癌细胞就会处于休眠状态，治疗起来就困难得多。休眠的癌细胞逃避常规的抗癌治疗，在它们变回“肿瘤生长”状态之前可以保持休眠很长一段时间。了解肿瘤细胞的癌起始（干细胞）特性是如何维持的，为消除持续性癌细胞提供了潜在的新途径。这些知识最终将导致更好的癌症管理和治疗，并提高生存率。对干细胞行为的理解也是控制退行性疾病的核心。