Degradation of antimicrobial agents Tylosin and Chlorotetracycline during swine waste treatment

猪粪处理过程中抗菌剂泰乐菌素和金霉素的降解

• 批准号: 0606986
• 负责人: James Stone
• 金额: --
• 依托单位: South Dakota School of Mines and Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0606986&HistoricalAwards=false
• 关键词: Degradation; antimicrobial; agents; Tylosin; Chlorotetracycline

0606986 Stone This project will evaluate the fate (degradation) and effects of two antimicrobials, tylosin and chlorotetracycline (CTC), in swine manure treatment (aerobic and anaerobic lagoons) and anaerobic sequencing batch reactors. These compounds are two of the most commonly administered antimicrobial agents to improve swine growth rates and prevent, control, and treat swine-related health problems in confined feedlots. The pervasive use of these antimicrobials in swine production makes the development of such information timely and important. The project has four research goals: (1) determine removal efficiencies of the antibiotics through laboratory based simulations of aerobic and anaerobic lagoon waste treatment processes; (2) assess the impacts of the antibiotics on psychrophilic (ca. 5-20oC) and mesophilic (ca. 30-38oC) aerobic and anaerobic lagoon treatment performance; (3) quantify changes in microbial community diversity and activity due to the antibiotics during aerobic and anaerobic waste treatment; and (4) determine changes in operational efficiency of anaerobic sequencing batch reactors (SBR) due to the antibiotics during treatment of swine waste. The broader impacts section of the project involves collaboration between two universities in South Dakota and participation by undergraduates and graduate students in the research.

0606986 Stone该项目将评估两种抗菌剂泰乐菌素和金霉素（CTC）在猪粪处理（好氧和厌氧泻湖）和厌氧序批式反应器中的命运（降解）和影响。这些化合物是两种最常用的抗菌剂，用于提高猪的生长速度，预防、控制和治疗封闭饲养场中与猪相关的健康问题。这些抗菌剂在养猪生产中的广泛使用使得这些信息的开发及时而重要。该项目有四个研究目标：（1）通过实验室模拟好氧和厌氧泻湖废物处理过程来确定抗生素的去除效率;（2）评估抗生素对嗜冷菌（ca. 5- 20 oC）和嗜温（约。30- 38 ℃）好氧和厌氧泻湖处理性能;（3）量化在好氧和厌氧废物处理过程中由于抗生素引起的微生物群落多样性和活性的变化;以及（4）确定在猪废物处理过程中由于抗生素引起的厌氧序批式反应器（SBR）的运行效率的变化。该项目更广泛的影响部分涉及南达科他州两所大学之间的合作以及本科生和研究生参与研究。