Molecular Evolution of Genes Expressed in D. Melanogaster Sperm Storage Structures.

黑腹果蝇精子储存结构中表达的基因的分子进化。

• 批准号: 0614503
• 负责人: Lawrence Harshman
• 金额: $ 28.32万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-11-01 至 2014-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0614503&HistoricalAwards=false
• 关键词: Molecular; Evolution; Genes; Expressed; D.

This project is designed to investigate genes expressed in sperm storage organs (SSOs) in female Drosophila melanogaster. SSOs potentially play an important role in a range of evolutionary phenomena including co-evolution and speciation. Given the prominent role of D. melanogaster as a model for evolutionary and genetic studies, it is surprising that so little is known about the evolution of genes characteristically expressed in SSOs and that little is known about the function of these genes. The investigators will examine the function of a set of these genes defined by molecular evolution data, molecular population genetic data and information suggesting that certain genes play a direct role in sperm storage. The sequences generated from this project will be deposited in the public database, NCBI/GenBank, in timely manner. A project website will be developed to provide information about the progress of the research and to provide the research community access to all sequence data. The grant will contribute to educational outcomes in various ways. First, both graduate and undergraduate students will be involved in the research. Second, the co-PI (Moriyama) will incorporate statistical methods used in the project and the results into her course. Third, the PI (Harshman) will expand the population genetic component of his honors human genetics course and its graduate student counterpart.

本项目旨在研究雌性果蝇精子贮存器官（SSO）中的基因表达。SSO在一系列进化现象中可能发挥重要作用，包括共同进化和物种形成。鉴于D.尽管将黑腹果蝇作为进化和遗传研究的模型，但令人惊讶的是，对在SSO中特征性表达的基因的进化知之甚少，并且对这些基因的功能知之甚少。研究人员将检查一组这些基因的功能，这些基因由分子进化数据、分子群体遗传数据和表明某些基因在精子储存中起直接作用的信息定义。该项目产生的序列将及时存入公共数据库NCBI/GenBank。将开发一个项目网站，提供有关研究进展的信息，并向研究界提供所有序列数据。 赠款将以各种方式促进教育成果。首先，研究生和本科生都将参与研究。 第二，共同PI（森山）将把项目中使用的统计方法和结果纳入她的课程。第三，PI（Harshman）将扩大他的荣誉人类遗传学课程及其研究生对应的人口遗传学部分。