RUI: Synthesis, structural characterization, and catalytic hydroamination activity of chiral, tethered cyclopentadienyl-amide-alkoxide complexes of group IV and V metals

RUI:IV族和V族金属手性束缚环戊二烯基-酰胺-醇盐配合物的合成、结构表征和催化加氢胺化活性

基本信息

  • 批准号:
    0615724
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-09-01 至 2010-08-31
  • 项目状态:
    已结题

项目摘要

The Inorganic, Bioinorganic and Organometallic Chemistry Program supports the research of Adam R. Johnson of the Department of Chemistry at Harvey Mudd College and Katherine A. Kantardjieff of the Department of Chemistry and Biochemistry, California State University Fullerton, investigating catalytic hydroamination reactions as highly atom economical methods of synthesizing substituted amines. A hydroamination reactions adds a N-H bond across a C-C multiple bond - these reactions are particularly useful for the synthesis of fine chemicals and pharmacologically active molecules. This research project has three specific aims: 1) the synthesis of tethered cyclopentadienyl-amide-alkoxide ligands and their corresponding titanium and tantalum complexes, 2) the crystallographic characterization of the new organometallic complexes and 3) the study of catalytic hydroamination reactions performed with the novel metal complexes. The proposed research will provide undergraduate students at Harvey Mudd College with experience in organic and inorganic synthesis as well as x-ray crystallography. The structure determination work will take place at the W.M. Keck Foundation Center for Molecular Structure at California State University Fullerton.
无机、生物无机和有机金属化学项目支持Harvey Mudd学院化学系的Adam R. Johnson和加州州立大学富勒顿分校化学和生物化学系的Katherine A. kantardjeff的研究,研究催化氢胺化反应作为高度原子经济的合成取代胺的方法。氢胺化反应在C-C多键上增加一个N-H键,这些反应对于精细化学品和具有药理活性的分子的合成特别有用。本研究项目有三个具体目标:1)系链环戊二烯酰胺-醇氧体配体及其相应的钛和钽配合物的合成;2)新型有机金属配合物的晶体学表征;3)新型金属配合物催化氢胺化反应的研究。拟议的研究将为哈维马德学院的本科生提供有机和无机合成以及x射线晶体学的经验。结构测定工作将在加州州立大学富勒顿分校的W.M.凯克分子结构基金会中心进行。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Adam Johnson其他文献

Primary tracheoesophageal puncture in salvage laryngectomy patients
挽救性喉切除术患者的初次气管食管穿刺
  • DOI:
    10.1002/lary.24002
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Adam Johnson;T. Grammer;J. Medina
  • 通讯作者:
    J. Medina
TPL2 kinase action and control of inflammation
TPL2 激酶作用和炎症控制
  • DOI:
    10.4049/jimmunol.204.supp.152.3
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    4.4
  • 作者:
    Daqi Xu;Y. Kwon;K. Senger;Victoria Pham;Eugene Varfolomeev;George Francis;Jason A. Hackney;Brendan Parr;Nisha Rathore;Francesca Setiadi;Gladys Boenig;Seth Harris;Patrick Lupardus;Marissa Matsumoto;Yuanyuan Wang;Jesse Hanson;Jonathan Maher;Kai Wu;Andrey Shaw;Alexis Scherl;Jiansheng Wu;Cheng Lu;Zhiyu Huang;Juan Zhang;Summer Park;Swathi Sujatha;Alice Almazan;Min Xu;P. Caplazi;H. Brightbill;N. Ghilardi;Michael Townsend;Wyne P. Lee;Adam Johnson;Brent McKenzie;Ali A. Zarrin;Mark Wilson
  • 通讯作者:
    Mark Wilson
TCT-95 Role of Pulmonary Artery Catheter Utilization in Different SCAI Classifications in Patients With Acute Myocardial Infarction and Cardiogenic Shock: Analysis From a Large US Healthcare System
  • DOI:
    10.1016/j.jacc.2022.08.115
  • 发表时间:
    2022-09-20
  • 期刊:
  • 影响因子:
  • 作者:
    Mohit Pahuja;Aakash Tuli;Akhil Kallur;Abhinav Saxena;Adam Johnson;Cheng Zhang;Steven Rappaport;Hayder Hashim;Lowell Satler;Itsik Ben-Dor;Ron Waksman
  • 通讯作者:
    Ron Waksman
Molecular pharmacodynamics of meropenem for nosocomial pneumonia caused by emPseudomonas aeruginosa/em
美罗培南对铜绿假单胞菌引起的医院获得性肺炎的分子药效学
  • DOI:
    10.1128/mbio.03165-23
  • 发表时间:
    2024-01-23
  • 期刊:
  • 影响因子:
    4.700
  • 作者:
    Nicola Farrington;Vineet Dubey;Adam Johnson;Iona Horner;Adam Stevenson;Jennifer Unsworth;Ana Jimenez-Valverde;Julie Schwartz;Shampa Das;William Hope;Christopher A. Darlow
  • 通讯作者:
    Christopher A. Darlow
PULMONARY HYPERTENSION IS ASSOCIATED WITH WORSE TAVR OUTCOMES INDEPENDENT OF COPD: REPORT FROM THE TVT REGISTRY
  • DOI:
    10.1016/s0735-1097(16)30003-1
  • 发表时间:
    2016-04-05
  • 期刊:
  • 影响因子:
  • 作者:
    Creighton W. Don;Adam Johnson;Amanda Stebbins;Sreekanth Vemulapalli;Roland Matsouaka;Chris Burke;Steve Le;Edward Verrier;Larry Dean;Mark Reisman;Gabriel Aldea
  • 通讯作者:
    Gabriel Aldea

Adam Johnson的其他文献

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{{ truncateString('Adam Johnson', 18)}}的其他基金

RUI: Asymmetric catalytic hydroamination of aminoallenes by chiral tantalum cyclopentadienyl-amide-alkoxide complexes
RUI:手性钽环戊二烯基-酰胺-醇盐络合物对氨基丙二烯的不对称催化氢氨化
  • 批准号:
    1012445
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
REU Site: Chemistry Research Experiences for Undergraduates at Harvey Mudd College
REU 网站:哈维穆德学院本科生化学研究经历
  • 批准号:
    0648597
  • 财政年份:
    2007
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant

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  • 批准号:
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