RUI: Synthesis, structural characterization, and catalytic hydroamination activity of chiral, tethered cyclopentadienyl-amide-alkoxide complexes of group IV and V metals

RUI：IV族和V族金属手性束缚环戊二烯基-酰胺-醇盐配合物的合成、结构表征和催化加氢胺化活性

• 批准号: 0615724
• 负责人: Adam Johnson
• 金额: --
• 依托单位: Harvey Mudd College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0615724&HistoricalAwards=false
• 关键词: RUI; Synthesis; structural; characterization; catalytic

The Inorganic, Bioinorganic and Organometallic Chemistry Program supports the research of Adam R. Johnson of the Department of Chemistry at Harvey Mudd College and Katherine A. Kantardjieff of the Department of Chemistry and Biochemistry, California State University Fullerton, investigating catalytic hydroamination reactions as highly atom economical methods of synthesizing substituted amines. A hydroamination reactions adds a N-H bond across a C-C multiple bond - these reactions are particularly useful for the synthesis of fine chemicals and pharmacologically active molecules. This research project has three specific aims: 1) the synthesis of tethered cyclopentadienyl-amide-alkoxide ligands and their corresponding titanium and tantalum complexes, 2) the crystallographic characterization of the new organometallic complexes and 3) the study of catalytic hydroamination reactions performed with the novel metal complexes. The proposed research will provide undergraduate students at Harvey Mudd College with experience in organic and inorganic synthesis as well as x-ray crystallography. The structure determination work will take place at the W.M. Keck Foundation Center for Molecular Structure at California State University Fullerton.

无机、生物无机和有机金属化学项目支持Harvey Mudd学院化学系的Adam R. Johnson和加州州立大学富勒顿分校化学和生物化学系的Katherine A. kantardjeff的研究，研究催化氢胺化反应作为高度原子经济的合成取代胺的方法。氢胺化反应在C-C多键上增加一个N-H键，这些反应对于精细化学品和具有药理活性的分子的合成特别有用。本研究项目有三个具体目标：1)系链环戊二烯酰胺-醇氧体配体及其相应的钛和钽配合物的合成；2)新型有机金属配合物的晶体学表征；3)新型金属配合物催化氢胺化反应的研究。拟议的研究将为哈维马德学院的本科生提供有机和无机合成以及x射线晶体学的经验。结构测定工作将在加州州立大学富勒顿分校的W.M.凯克分子结构基金会中心进行。