RUI: Synthesis, structural characterization, and catalytic hydroamination activity of chiral, tethered cyclopentadienyl-amide-alkoxide complexes of group IV and V metals

无机，生物无机和有机化学计划支持亚当R。哈维马德学院化学系的约翰逊和凯瑟琳A。加州州立大学富勒顿化学和生物化学系的Kantardjieff研究了催化加氢胺化反应作为合成取代胺的高度原子经济的方法。 加氢胺化反应在C-C多重键上添加N-H键-这些反应特别适用于精细化学品和生物活性分子的合成。 本研究项目有三个具体目标：1）合成栓系环戊二烯基酰胺醇盐配体及其相应的钛和钽配合物，2）新的金属有机配合物的晶体学表征和3）研究与新型金属配合物进行的催化氢胺化反应。 这项拟议中的研究将为哈维穆德学院的本科生提供有机和无机合成以及X射线晶体学方面的经验。 结构确定工作将在W.M.进行。加州州立大学富勒顿的凯克基金会分子结构中心。

The Inorganic, Bioinorganic and Organometallic Chemistry Program supports the research of Adam R. Johnson of the Department of Chemistry at Harvey Mudd College and Katherine A. Kantardjieff of the Department of Chemistry and Biochemistry, California State University Fullerton, investigating catalytic hydroamination reactions as highly atom economical methods of synthesizing substituted amines. A hydroamination reactions adds a N-H bond across a C-C multiple bond - these reactions are particularly useful for the synthesis of fine chemicals and pharmacologically active molecules. This research project has three specific aims: 1) the synthesis of tethered cyclopentadienyl-amide-alkoxide ligands and their corresponding titanium and tantalum complexes, 2) the crystallographic characterization of the new organometallic complexes and 3) the study of catalytic hydroamination reactions performed with the novel metal complexes. The proposed research will provide undergraduate students at Harvey Mudd College with experience in organic and inorganic synthesis as well as x-ray crystallography. The structure determination work will take place at the W.M. Keck Foundation Center for Molecular Structure at California State University Fullerton.