Visualisation of herpes virus infections and immune responses as well as their modulation (B01)

B1项目的目的是更好地了解免疫细胞和病毒感染细胞之间的相互作用，以及感染细胞如何在体内被杀死。在最后一个资助期，我们调查了CD8+T细胞和NK细胞在淋巴结和皮肤中的杀伤能力，并比较了MCMV熟练和MCK-2缺陷的MCMV在新生小鼠肺中的趋向性。在下一个资金阶段，我们的目标是了解细胞毒CD8+T细胞和NK细胞在杀伤病毒感染细胞方面的异质性和协同性。此外，我们的目标是破译髓系细胞在围绕受感染细胞创造环境中的作用，这有助于控制病毒向邻近细胞的传播。

The aim of the project B1 is to better understand interactions between immune cells and virus-infected cells and how infected cells get killed in vivo. In the last funding period we investigated the killing capacities of CD8+ T cells and NK cells in lymph nodes and skin and compared the viral tropism of MCMV proficient and deficient for MCK-2 in lungs of neonatal mice. In the next funding period, we aim to understand the heterogeneity and cooperativity of cytotoxic CD8+ T cells as well as NK cells in killing virus-infected cells. Furthermore we aim to decipher the role of myeloid cells in creating an environment around infected cells that contributes control virus-spread to neighboring cells.